5-hydroxytryptamine receptor 2A (HTR2A)

Also functions as a receptor for a variety of drugs and psychoactive substances, including mescaline, psilocybin, 1-(2,5-dimethoxy-4- iodophenyl)-2-aminopropane (DOI) and lysergic acid diethylamide (LSD) (PubMed:28129538). Ligand binding causes a conformation change that activates signaling through guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors (PubMed:28129538).

Beta-arrestin family members inhibit signaling through G proteins and mediate activation of alternative signaling pathways (PubMed:28129538). Signaling activates phospholipase C and a phosphatidylinositol-calcium second messenger system which modulates the activity of phosphatidylinositol 3-kinase and promotes the release of Ca(2+) ions from intracellular stores (PubMed:18703043, PubMed:28129538).