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- Table of Contents
HTRA2 Antibodies
AND HTRA2 ELISA kits, HTRA2 Proteins
Many biological assays use antibodies to detect HTRA2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with HTRA2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop HTRA2 antibodies...
Designing a Western blot for HTRA2? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the HTRA2 Western Blot GuideDesigning an IHC experiment for HTRA2? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the HTRA2 IHC GuideHTRA2 Infographic by Boster Bio
All HTRA2 Products
Product
Figures
Specificity
Applications
Price
Human
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A01941-3
100 µg/vial
Cat # A01941-3
100 µg/vial
HTRA2 Overview
Facts about Serine protease HTRA2, mitochondrial.
Serine protease HTRA2, mitochondrial (HTRA2)
Serine protease that shows proteolytic activity against a non-specific substrate beta-casein. Promotes or induces cell death either by direct binding to and inhibition of BIRC proteins (also called inhibitor of apoptosis proteins, IAPs), resulting in an increase in caspase activity, or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism.
Cleaves THAP5 and promotes its degradation during apoptosis. Isoform 2 appears to be proteolytically inactive.
Gene Information
| Human | |
|---|---|
| Gene Name: | HTRA2 |
| Uniprot: | O43464 |
| Entrez: | 27429 |
Family
| Belongs to: |
|---|
| peptidase S1C family |
Alternative Names
High temperature requirement protein A2; HtrA serine peptidase 2; HTRA2; HtrA-like serine protease; Omi; OMIOmi stress-regulated endoprotease; PARK13EC 3.4.21.108; PRSS25; PRSS25serine, 25; Serine protease 25; serine protease HTRA2, mitochondrial; Serine proteinase OMI
Molecular Weight
Mass (kDA):
48.841 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 2p13.1 |
| Sequence: | 2; NC_000002.12 (74529405..74533556) |
Tissue Specificity
Isoform 1 is ubiquitous. Isoform 2 is expressed predominantly in the kidney, colon and thyroid.
Subcellular Localizations
Mitochondrion intermembrane space. Mitochondrion membrane; Single-pass membrane protein. Predominantly present in the intermembrane space. Released into the cytosol following apoptotic stimuli, such as UV treatment, and stimulation of mitochondria with caspase-8 truncated BID/tBID.
Diseases
- Malignant Neoplasms
- Parkinson Disease
- Neoplasms
- Neurodegenerative Disorders
- Nerve Degeneration
- Leukemia
- Carcinoma
- Alzheimer's Disease
- Malignant Paraganglionic Neoplasm
- Ischemia
- Infarction
- Lymphoma
Interacting Proteins
- BIRC7
- NDUFA13
- Ripk1
- XIAP
Pathways
- Cell Death
- Pathogenesis
- Programmed Cell Death
- Induction Of Apoptosis
- Proteolysis
- Autophagy
- Cell Cycle
- Localization
- Rna Interference
- Mitochondrial Outer Membrane Permeabilization
- Sensitization
- Cell Growth
- Transport
PTMs
- Cleavage
- Phosphorylation
- Ubiquitination
- Reduction
- Methylation
Research Areas
- Apoptosis
- Cancer
- Mitochondrial-Mediated Pathway
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/HTRA2
bosterbio.com/bosterbio-gene-info-cards/HTRA2
References
PMID: 10644717 by Faccio L., et al. Characterization of a novel human serine protease that has extensive homology to bacterial heat shock endoprotease HtrA and is regulated by kidney ischemia.
PMID: 10971580 by Gray C.W., et al. Characterization of human HtrA2, a novel serine protease involved in the mammalian cellular stress response.