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- Table of Contents
ID2 Antibodies
AND ID2 ELISA kits, ID2 Proteins
Many biological assays use antibodies to detect ID2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with ID2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop ID2 antibodies...
Designing a Western blot for ID2? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the ID2 Western Blot GuideID2 Infographic by Boster Bio
All ID2 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
IF, IHC, WB
$523
Cat # M00417
100 µl
Cat # M00417
100 µl
ID2 Overview
Facts about DNA-binding protein inhibitor ID-2.
DNA-binding protein inhibitor ID-2 (ID2)
Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the simple helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation.
Inhibits skeletal muscle and cardiac myocyte differentiation. Regulates the circadian clock by repressing the transcriptional activator activity of this CLOCK-ARNTL/BMAL1 heterodimer.
Gene Information
| Human | |
|---|---|
| Gene Name: | ID2 |
| Uniprot: | Q02363 |
| Entrez: | 3398 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
BHLHB26; bHLHb26cell growth-inhibiting gene 8; Class B basic helix-loop-helix protein 26; DNA-binding protein inhibitor ID2; DNA-binding protein inhibitor ID-2; GIG8; helix-loop-helix protein ID2; ID2; ID2A; ID2H; inhibitor of differentiation 2; Inhibitor of DNA binding 2; inhibitor of DNA binding 2, dominant negative helix-loop-helix protein; MGC26389
Molecular Weight
Mass (kDA):
14.917 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 2p25.1 |
| Sequence: | 2; NC_000002.12 (8682056..8684461) |
Tissue Specificity
Highly expressed in early fetal tissues, including those of the central nervous system.
Subcellular Localizations
Cytoplasm. Nucleus.
Diseases
- Neoplasms
- Malignant Neoplasms
- Lymphohistiocytosis, Hemophagocytic
- Retinoblastoma
- Cell Transformation, Neoplastic
- Nervousness
- Neuroblastoma
- Carcinoma
- Malignant Paraganglionic Neoplasm
- Neoplasm Metastasis
- Leukemia
- Lymphoma
- Hyperplasia
Interacting Proteins
- CCNDBP1
- PDLIM5
- PKD2
- TCF12
- TCF4
Pathways
- Cell Cycle
- Cell Proliferation
- Cell Differentiation
- Cell Growth
- Cell Development
- Localization
- Neurogenesis
- Cell Cycle Arrest
- Angiogenesis
- Pathogenesis
- Rna Interference
- Immune Response
- Regeneration
PTMs
- Phosphorylation
- Methylation
- Cleavage
- Acetylation
- Ubiquitination
- Demethylation
Research Areas
- Cancer
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ID2
bosterbio.com/bosterbio-gene-info-cards/ID2
References
PMID: 8294468 by Hara E., et al. Id-related genes encoding helix-loop-helix proteins are required for G1 progression and are repressed in senescent human fibroblasts.
PMID: 1741406 by Biggs J., et al. A human Id-like helix-loop-helix protein expressed during early development.