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Indian hedgehog protein Antibodies
AND IHH ELISA kits, Indian hedgehog protein Proteins
Many biological assays use antibodies to detect Indian hedgehog protein, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Indian hedgehog protein in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Indian hedgehog protein antibodies...
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IHH Infographic by Boster Bio
All IHH Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, IHC, WB
$370
Cat # A01448-1
100 μg/vial
Cat # A01448-1
100 μg/vial
IHH Overview
Facts about Indian hedgehog protein.
Indian hedgehog protein (IHH)
Intercellular signal essential for a variety of patterning events during development. Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes.
Implicated in endochondral ossification: may regulate the balance between growth and ossification of the developing bones. Induces the expression of parathyroid hormone-related protein (PTHRP) (By similarity).
Gene Information
| Human | |
|---|---|
| Gene Name: | IHH |
| Uniprot: | Q14623 |
| Entrez: | 3549 |
Family
| Belongs to: |
|---|
| hedgehog family |
Alternative Names
BDA1; BDA1Indian hedgehog homolog (Drosophila); HHG2; HHG-2; Ihh; Indian hedgehog (Drosophila) homolog; Indian hedgehog homolog; indian hedgehog protein; Indian Hedgehog
Molecular Weight
Mass (kDA):
45.251 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 2q35 |
| Sequence: | 2; NC_000002.12 (219054424..219060921, complement) |
Tissue Specificity
Expressed in embryonic lung, and in adult kidney and liver.
Subcellular Localizations
[Indian hedgehog protein N-product]: Cell membrane; Lipid-anchor; Extracellular side. The N-terminal peptide remains associated with the cell surface.; [Indian hedgehog protein C-product]: Secreted, extracellular space. The C-terminal peptide diffuses from the cell.; Cell membrane.
Diseases
- Hypertrophy
- Hypogonadism
- Hypogonadotropic Hypogonadism
- Malignant Neoplasms
- Idiopathic Hypogonadotropic Hypogonadism
- Neoplasms
- Kallmann Syndrome
- Carcinoma
- Dysplasia
- Brachydactyly
- Dwarfism
- Carcinogenesis
- Anosmia
Interacting Proteins
- BOC
Pathways
- Ossification
- Chondrocyte Differentiation
- Chondrocyte Proliferation
- Endochondral Ossification
- Cell Proliferation
- Secretion
- Bone Development
- Osteoblast Differentiation
- Chondrocyte Hypertrophy
- Localization
- Cell Differentiation
- Pathogenesis
- Regeneration
PTMs
- Phosphorylation
- Cleavage
- Methylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/IHH
bosterbio.com/bosterbio-gene-info-cards/IHH
References
PMID: 7590746 by Marigo V., et al. Cloning, expression, and chromosomal location of SHH and IHH: two human homologues of the Drosophila segment polarity gene hedgehog.
PMID: 7720571 by Chang D.T., et al. Products, genetic linkage and limb patterning activity of a murine hedgehog gene.