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- Table of Contents
Facts about Indian hedgehog protein.
Implicated in endochondral ossification: may regulate the balance between growth and ossification of the developing bones. Induces the expression of parathyroid hormone-related protein (PTHRP) (By similarity).
Human | |
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Gene Name: | IHH |
Uniprot: | Q14623 |
Entrez: | 3549 |
Belongs to: |
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hedgehog family |
BDA1; BDA1Indian hedgehog homolog (Drosophila); HHG2; HHG-2; Ihh; Indian hedgehog (Drosophila) homolog; Indian hedgehog homolog; indian hedgehog protein; Indian Hedgehog
Mass (kDA):
45.251 kDA
Human | |
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Location: | 2q35 |
Sequence: | 2; NC_000002.12 (219054424..219060921, complement) |
Expressed in embryonic lung, and in adult kidney and liver.
[Indian hedgehog protein N-product]: Cell membrane; Lipid-anchor; Extracellular side. The N-terminal peptide remains associated with the cell surface.; [Indian hedgehog protein C-product]: Secreted, extracellular space. The C-terminal peptide diffuses from the cell.; Cell membrane.
PMID: 7590746 by Marigo V., et al. Cloning, expression, and chromosomal location of SHH and IHH: two human homologues of the Drosophila segment polarity gene hedgehog.
PMID: 7720571 by Chang D.T., et al. Products, genetic linkage and limb patterning activity of a murine hedgehog gene.