Many biological assays use antibodies to detect Protein Red, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Protein Red in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Protein Red antibodies...
We validate the specificity of these antibodies to Protein Red by testing them on tissues known to express IK positively and negatively. Browse below to find the IK antibody that suites your experiment. We have 78 of these antibodies and many publications and validation images.
If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.
$480 Cat # EKC1312 1 kit, containing one 96-well plate and all necessary reagents
IK Overview
Facts about Protein Red.
Protein Red (IK)
Involved in pre-mRNA splicing as a part of the spliceosome (PubMed:28781166). Auxiliary spliceosomal protein that modulates selection of alternative splice sites in a small set of goal pre-mRNA species (Probable).
Required for normal mitotic cell cycle progression (PubMed:22351768, PubMed:24252166). Recruits MAD1L1 and MAD2L1 to kinetochores, and is needed to trigger the spindle assembly checkpoint (PubMed:22351768).
Gene Information
Human
Gene Name:
IK
Uniprot:
Q13123
Entrez:
3550
Family
Belongs to:
RED family
Alternative Names
chondrosarcoma-associated protein 2; CSA2; Cytokine IK; IK cytokine, down-regulator of HLA II; IK factor; MGC59741; protein Red; Protein RER; RD element; REDprer protein; RER
Molecular Weight
Mass (kDA): 65.602 kDA
Genomic Context
Human
Location:
5q31.3
Sequence:
5; NC_000005.10 (140647818..140662480)
Tissue Specificity
Ubiquitous.
Subcellular Localizations
Nucleus. Nucleus, nucleoplasm. Chromosome. Cytoplasm, cytoskeleton, spindle pole. Predominantly present throughout the nucleoplasm during prometaphase, metaphase and anaphase. Is also detected in nuclear foci that are not identical with Cajal bodies. Starts to accumulate at chromosomes during telophase, and is nearly exclusively associated with chromosomes in newly divided cells (PubMed:24252166). Colocalizes with MAD1L1 at mitotic spindle poles during metaphase and anaphase (PubMed:22351768).
Diseases
Cardiac Arrhythmia
Pertussis
Ischemia
Depressive Disorder
Hypoxia
Pituitary Diseases
Cardiac Fibrillation
Neoplasms
Hypertensive Disease
Nervousness
Pathologic Vasoconstriction
Anoxia
Neuroblastoma
Patient Dependence On
Malignant Neoplasms
Glioma
Ventricular Fibrillation
Myocardial Ischemia
Edema
Atrial Fibrillation
Interacting Proteins
AURKA
CEP70
EFTUD2
FRA10AC1
MFAP1
PRPF6
RBM10
RNF113A
SMU1
SNIP1
XAB2
ZNF830
Pathways
Secretion
Membrane Depolarization
Transport
Membrane Hyperpolarization
Cell Proliferation
Localization
Vasodilation
Vasoconstriction
Cell Cycle
Pathogenesis
Cell Growth
Synaptic Transmission
Aging
Immune Response
Cell Death
Protein Phosphorylation
Glycosylation
Translation
Muscle Contraction
Cell Differentiation
PTMs
Phosphorylation
Reduction
Dephosphorylation
Glycosylation
Oxidation
Nitration
Methylation
Ubiquitination
Cleavage
Acetylation
Myristoylation
Sumoylation
Demethylation
Phosphorothioation
Ribosylation
Iodination
Deacetylation
Research Areas
Cytokine Research
For details, visit: bosterbio.com/bosterbio-gene-info-cards/IK
References
PMID: 10216252 by Assier E., et al. Isolation, sequencing and expression of RED, a novel human gene encoding an acidic-basic dipeptide repeat.
PMID: 7970704 by Krief P., et al. A new cytokine (IK) down-regulating HLA class II: monoclonal antibodies, cloning and chromosome localization.
23 Publications of Boster Protein Red Antibodies & ELISA Kits
PubMed ID: 10.4314/tjpr.v16i11.13, Prophylactic effects of triptolide on colon cancer development in azoxymethane/d...
PubMed ID: 10.3390/antiox10020176, Gastro-Protective Effects of Albizia anthelmintica Leaf Extract on Indomethacin-...
PubMed ID: 10.3389/fphys.2021.707344, Pioglitazone Ameliorates Renal Ischemia-Reperfusion Injury via Inhibition of NF-...
PubMed ID: 10.3109/13880209.2014.898075, Effect of ammonium pyrrolidine dithiocarbamate (PDTC) on NF-κB activation and C...