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Receptor for IL17A and IL17F homodimers as part of a heterodimeric complex with IL17RA (PubMed:16785495).Receptor for the heterodimer formed by IL17A and IL17B as part of a heterodimeric complex with IL17RA (PubMed:18684971).
Has also been shown to be the cognate receptor for IL17F and to bind IL17A with high affinity with no need for IL17RA (PubMed:17911633). Activation of IL17RC contributes to induction of expression of inflammatory chemokines and cytokines like CXCL1 (PubMed:16785495).
|Sequence:||3; NC_000003.12 (9917074..9933627)|
Expressed in prostate, skeletal muscle, kidney and placenta (at protein level) (PubMed:11706037). Expressed in brain, cartilage, colon, heart, intestine, kidney, liver, lung, muscle, placenta, and prostate (PubMed:11706037). Also detected in thyroid, trachea and adrenal gland (PubMed:17911633). Low expression in thymus and leukocytes (PubMed:11706037).
Cell membrane; Single-pass type I membrane protein. Soluble isoforms may be produced.