- Table of Content
Within the IL18 receptor complex, responsible for the binding of This proinflammatory cytokine IL18, but not IL1A nor IL1B (PubMed:8626725, PubMed:14528293, PubMed:25261253, PubMed:25500532).Involved in IL18-mediated IFNG synthesis from T- helper 1 (Th1) cells (PubMed:10653850).
Contributes to IL18- induced cytokine production, either independently of SLC12A3, or as a complex with SLC12A3 (By similarity). .
|interleukin-1 receptor family|
|Sequence:||2; NC_000002.12 (102355796..102398777)|
Highly expressed in leukocytes, spleen, lung. Also expressed, but at lower levels, in liver, small intestine, colon, prostate, thymus, placenta, and heart. Specifically coexpressed with IL18R1 in Th1 cells (PubMed:10925275, PubMed:11046021, PubMed:10653850).
Membrane; Single-pass type I membrane protein.