Interleukin-18 receptor 1 (IL18R1)

Within the IL18 receptor complex, responsible for the binding of This proinflammatory cytokine IL18, but not IL1A nor IL1B (PubMed:8626725, PubMed:14528293, PubMed:25261253, PubMed:25500532).

Involved in IL18-mediated IFNG synthesis from T- helper 1 (Th1) cells (PubMed:10653850).

Contributes to IL18- induced cytokine production, either independently of SLC12A3, or as a complex with SLC12A3 (By similarity). .