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- Table of Contents
IQGAP1 Antibodies
AND IQGAP1 ELISA kits, IQGAP1 Proteins
Many biological assays use antibodies to detect IQGAP1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with IQGAP1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop IQGAP1 antibodies...
Designing a Western blot for IQGAP1? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the IQGAP1 Western Blot GuideIQGAP1 Infographic by Boster Bio
All IQGAP1 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A01603
100 μg/vial
Cat # A01603
100 μg/vial
Human
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A01603-1
100 μg/vial
Cat # A01603-1
100 μg/vial
Human, Mouse
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # M01603
100 μl
Cat # M01603
100 μl
IQGAP1 Overview
Facts about Ras GTPase-activating-like protein IQGAP1.
Ras GTPase-activating-like protein IQGAP1 (IQGAP1)
Plays a vital role in regulating the dynamics and assembly of the actin cytoskeleton. Binds to activated CDC42 but doesn't stimulate its GTPase activity.
It partners with calmodulin. Could function as a meeting scaffold for the organization of a multimolecular complex that would interface incoming signals to the reorganization of the actin cytoskeleton in the plasma membrane.
Gene Information
| Human | |
|---|---|
| Gene Name: | IQGAP1 |
| Uniprot: | P46940 |
| Entrez: | 8826 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
HUMORFA01; IQ motif containing GTPase activating protein 1; IQGAP1; KIAA0051ras GTPase-activating-like protein IQGAP1; p195; p195RasGAP-like with IQ motifs; SAR1
Molecular Weight
Mass (kDA):
189.252 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 15q26.1 |
| Sequence: | 15; NC_000015.10 (90388242..90502239) |
Tissue Specificity
Expressed in the placenta, lung, and kidney. A lower level expression is seen in the heart, liver, skeletal muscle and pancreas.
Subcellular Localizations
Cell membrane. Nucleus. Cytoplasm. Subcellular distribution is regulated by the cell cycle, nuclear levels increase at G1/S phase (PubMed:20883816).
Diseases
- Tissue Adhesions
- Malignant Neoplasms
- Neoplasms
- Carcinoma
- Cell Invasion
- Neoplasm Metastasis
- Neoplasm Invasiveness
- Adenomatous Polyposis Coli
- Polyposis
- Adenocarcinoma
- Cell Transformation, Neoplastic
- Malignant Neoplasm Of Stomach
- Malignant Neoplasm Of Breast
Interacting Proteins
- ACTN4
- BCAR1
- BRAF
- CD2AP
- CDC42
- CTNNB1
- CXCR2
- Diaph1
- EGFR
- ERBB2
Pathways
- Localization
- Cell Migration
- Cell-cell Adhesion
- Cell Adhesion
- Cell Proliferation
- Cell Motility
- Cytokinesis
- Cell Cycle
- Angiogenesis
- Secretion
- Transport
- Wound Healing
- Cell Growth
PTMs
- Phosphorylation
- Dephosphorylation
- Methylation
Research Areas
- Signal Transduction
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/IQGAP1
bosterbio.com/bosterbio-gene-info-cards/IQGAP1
References
PMID: 8051149 by Weissbach L., et al. Identification of a human rasGAP-related protein containing calmodulin-binding motifs.
PMID: 15355962 by Grohmanova K., et al. Phosphorylation of IQGAP1 modulates its binding to Cdc42, revealing a new type of rho-GTPase regulator.