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- Table of Contents
IRF7 Antibodies
AND IRF7 ELISA kits, IRF7 Proteins
Many biological assays use antibodies to detect IRF7, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with IRF7 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop IRF7 antibodies...
Designing a Western blot for IRF7? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the IRF7 Western Blot GuideDesigning an IHC experiment for IRF7? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the IRF7 IHC GuideIRF7 Infographic by Boster Bio
All IRF7 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
Flow Cytometry, IP, IF, IHC, ICC, WB
$370
Cat # M00115
100 μl
Cat # M00115
100 μl
IRF7 Overview
Facts about Interferon regulatory factor 7.
Interferon regulatory factor 7 (IRF7)
Key transcriptional regulator of type I interferon (IFN)-dependent immune responses and plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters.
Can effectively activate both the IFN-beta (IFNB) and the IFN-alpha (IFNA) genes and mediate their induction via both the virus-activated, MyD88- independent pathway and the TLR-activated, MyD88-dependent pathway. Required during both the early and late phases of the IFN gene induction but is more critical for the late compared to the early phase.
Gene Information
| Human | |
|---|---|
| Gene Name: | IRF7 |
| Uniprot: | Q92985 |
| Entrez: | 3665 |
Family
| Belongs to: |
|---|
| IRF family |
Alternative Names
interferon regulatory factor 7; interferon regulatory factor-7H; IRF-7; IRF7A; IRF-7H
Molecular Weight
Mass (kDA):
54.278 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 11p15.5 |
| Sequence: | 11; NC_000011.10 (612555..615999, complement) |
Tissue Specificity
Expressed predominantly in spleen, thymus and peripheral blood leukocytes.
Subcellular Localizations
Nucleus. Cytoplasm. The phosphorylated and active form accumulates selectively in the nucleus.
Diseases
- Virus Diseases
- Innate Immune Response
- Infective Disorder
- Inflammation
- Malignant Neoplasms
- Neoplasms
- Autoimmune Reaction
- Hepatitis
- Lupus Erythematosus, Systemic
- Autoimmune Diseases
- Stomatitis
- Influenza
Interacting Proteins
- AIP
- ARAF
- CCDC47
- CHUK
- IRAK1
- LTN1
- PALD1
- TBK1
- TLK2
- TRMT61B
Pathways
- Immune Response
- Pathogenesis
- Innate Immune Response
- Secretion
- Viral Replication
- Response To Virus
- Cytokine Production
- Localization
- Cell Growth
- Methylation
- Type I Interferon Production
- Cell Cycle
- Cell Death
PTMs
- Phosphorylation
- Ubiquitination
- Methylation
- Sumoylation
Research Areas
- Transcription Factors and Regulators
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/IRF7
bosterbio.com/bosterbio-gene-info-cards/IRF7
References
PMID: 9315633 by Zhang L., et al. IRF-7, a new interferon regulatory factor associated with Epstein- Barr virus latency.
PMID: 9786932 by Au W.-C., et al. Characterization of the interferon regulatory factor-7 and its potential role in the transcription activation of interferon A genes.