IST1 homolog Antibodies

AND IST1 ELISA kits, IST1 homolog Proteins

Many biological assays use antibodies to detect IST1 homolog, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with IST1 homolog in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop IST1 homolog antibodies...

We validate the specificity of these antibodies to IST1 homolog by testing them on tissues known to express IST1 positively and negatively. Browse below to find the IST1 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Designing an IHC experiment for IST1 homolog? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.

Open the IST1 IHC Guide

IST1 Infographic by Boster Bio

All IST1 Products

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Applications

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Anti-hIST1/IST1 Antibody Picoband®

Western blot analysis of HIST1/IST1 using anti-HIST1/IST1 antibody (A05507-2)

IHC analysis of HIST1/IST1 using anti-HIST1/IST1 antibody (A05507-2)

Human, Mouse, Rat

ELISA, Flow Cytometry, IF, IHC, ICC, WB

$370
Cat # A05507-2
100 µg/vial

IST1 (NM_014761) Human Over-expression Lysate

Human

$628
Cat # LS009798
20 µg, 100 µg

IST1 Overview

Facts about IST1 homolog.

IST1 3D structure. Source: alphafold

IST1 homolog (IST1)

ESCRT-III-like protein involved in specific functions of the ESCRT machinery. Is needed for efficient abscission during cytokinesis, but not for HIV-1 budding.

The participation in the MVB pathway is not established. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells (PubMed:19129479, PubMed:19129480).

Gene Information

Human
Gene Name:	IST1
Uniprot:	P53990
Entrez:	9798

Family

Belongs to:

IST1 family

Alternative Names

IST1 homolog; increased sodium tolerance 1 homolog (yeast); OLC1

Molecular Weight

Mass (kDA):
39.751 kDA

Genomic Context


Human

Location:	16q22.2
Sequence:	16; NC_000016.10 (71894408..71931199)

Subcellular Localizations

Cytoplasmic vesicle. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Midbody. Nucleus envelope. Localizes to centrosome and midbody of dividing cells (PubMed:19129480, PubMed:19129479, PubMed:20719964). Colocalized with SPART to the ends of Flemming bodies during cytokinesis (PubMed:20719964). Localizes to the nuclear envelope during late anaphase (PubMed:26040712).

Diseases

Weakness
Nervous System Disorder
Spastic Paraplegia, Hereditary
Immunologic Deficiency Syndromes
Dysentery, Bacillary
Shigella Infections
Paraplegia
Disease Caused By Shigella Sonnei
Spastic Paraplegia
Troyer Syndrome
Muscle Spasticity
Infective Disorder

Muscular Atrophy
Physiological Stress
Variable Number Tandem Repeat
Flushing
Nervousness
Impairment (finding)
Hiv Infections

Interacting Proteins

APEH
ATXN1
CAPN7
CHMP1B
UBQLN1

Pathways

Transport
Cytokinesis
Abscission
Localization
Autolysis
Cell Division
Membrane Fission
Transposition
Sulfur Oxidation
Proteolysis
Endocytosis

Ovulation
Embryo Development
Phenotypic Switching
Estrus
Pathogenesis

PTMs

Phosphorylation

Oxidation

Ubiquitination

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/IST1

References

PMID: 12761501 by Matsuda A., et al. Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways.

PMID: 19129480 by Agromayor M., et al. Essential role of hIST1 in cytokinesis.