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- Table of Contents
Integrin alpha-6 Antibodies
AND ITGA6 ELISA kits, Integrin alpha-6 Proteins
Many biological assays use antibodies to detect Integrin alpha-6, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Integrin alpha-6 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Integrin alpha-6 antibodies...
Designing a Western blot for Integrin alpha-6? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the ITGA6 Western Blot GuideITGA6 Infographic by Boster Bio
All ITGA6 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
IF, IHC, ICC, WB
$370
Cat # M01693
100 μl
Cat # M01693
100 μl
Human, Mouse, Rat
ELISA, Flow Cytometry, WB
$370
Cat # A01693
100 μg/vial
Cat # A01693
100 μg/vial
Human
$960
Cat # LS003655
20 µg, 100 µg
Cat # LS003655
20 µg, 100 µg
ITGA6 Overview
Facts about Integrin alpha-6.
Integrin alpha-6 (ITGA6)
Integrin alpha-6/beta-1 (ITGA6:ITGB1) is a receptor for laminin on platelets (By similarity). Integrin alpha-6/beta-1 (ITGA6:ITGB1) is present in oocytes and is included in sperm-egg fusion (By similarity).
Integrin alpha-6/beta-4 (ITGA6:ITGB4) is a receptor for laminin in epithelial cells and it plays a critical structural role in the hemidesmosome (By similarity). ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is vital for NRG1-ERBB signaling (PubMed:20682778).
Gene Information
| Human | |
|---|---|
| Gene Name: | ITGA6 |
| Uniprot: | P23229 |
| Entrez: | 3655 |
Family
| Belongs to: |
|---|
| integrin alpha chain family |
Alternative Names
CD49 antigen-like family member F; CD49f antigen; CD49f; DKFZp686J01244; FLJ18737; Integrin alpha 6; integrin alpha-6; integrin alpha6B; integrin, alpha 6; ITGA6; ITGA6B; Platelet gpl; VLA-6
Molecular Weight
Mass (kDA):
126.606 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 2q31.1 |
| Sequence: | 2; NC_000002.12 (172427336..172506459) |
Tissue Specificity
Integrin alpha-6/beta-4 is predominantly expressed by epithelia. Isoforms containing segment X1 are ubiquitously expressed. Isoforms containing segment X1X2 are expressed in heart, kidney, placenta, colon, duodenum, myoblasts and myotubes, and in a limited number of cell lines; they are always coexpressed with the ubiquitous isoform containing segment X1. In some tissues (e.g. Salivary gland), isoforms containing cytoplasmic segment A and isoforms containing segment B are detected while in others, only isoforms containing one cytoplasmic segment are found (segment A in epidermis and segment B in kidney).
Subcellular Localizations
Cell membrane; Single-pass type I membrane protein. Cell membrane; Lipid-anchor.
Diseases
- Tissue Adhesions
- Epidermolysis Bullosa
- Malignant Neoplasms
- Atresia
- Junctional Epidermolysis Bullosa
- Epidermolysis Bullosa Junctionalis With Pyloric Atresia
- Bulla
- Neoplasms
- Neoplasm Metastasis
- Carcinoma
- Skin Diseases, Genetic
Interacting Proteins
- ITGB4
Pathways
- Cell Adhesion
- Pathogenesis
- Spermatogenesis
- Cell Growth
- Angiogenesis
- Immune Response
- Reverse Transcription
- Cell Cycle
- Cell Proliferation
- Rna Interference
- Inner Ear Development
- Flight
- Translation
PTMs
Research Areas
- Signal Transduction
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ITGA6
bosterbio.com/bosterbio-gene-info-cards/ITGA6
References
PMID: 1976638 by Tamura R.N., et al. Epithelial integrin alpha 6 beta 4: complete primary structure of alpha 6 and variant forms of beta 4.
PMID: 2070796 by Hogervorst F., et al. Molecular cloning of the human alpha 6 integrin subunit. Alternative splicing of alpha 6 mRNA and chromosomal localization of the alpha 6 and beta 4 genes.
1 Publications of Boster Integrin alpha-6 Antibodies & ELISA Kits
- PubMed ID: , A three-dimensional biomimetic peripheral nerve model for drug testing and disea...
*More publications can be found for each product on its corresponding product page