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- Table of Contents
ITK Antibodies
AND ITK ELISA kits, ITK Proteins
Many biological assays use antibodies to detect ITK, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with ITK in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop ITK antibodies...
Designing a Western blot for ITK? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the ITK Western Blot GuideITK Infographic by Boster Bio
All ITK Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
Flow Cytometry, IP, IF, IHC, ICC, WB
$370
Cat # M02828
100 μl
Cat # M02828
100 μl
ITK Overview
Facts about Tyrosine-protein kinase ITK/TSK.
Tyrosine-protein kinase ITK/TSK (ITK)
Tyrosine kinase that plays an essential role in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells.
When antigen presenting cells (APC) trigger T-cell receptor (TCR), a series of phosphorylation lead to the recruitment of ITK into the cell membrane, in the vicinity of the aroused TCR receptor, where it is phosphorylated by LCK. Phosphorylation leads to ITK autophosphorylation and complete activation.
Gene Information
| Human | |
|---|---|
| Gene Name: | ITK |
| Uniprot: | Q08881 |
| Entrez: | 3702 |
Family
| Belongs to: |
|---|
| protein kinase superfamily |
Alternative Names
EC 2.7.10; EC 2.7.10.2; EMT; EMTMGC126257; homolog of mouse T-cell itk/tsk; IL2-inducible T-cell kinase; ITK; Kinase EMT; LYK; LYKMGC126258; PSCTK2; T-cell-specific kinase; Tcsk; tyrosine-protein kinase ITK/TSK; Tyrosine-protein kinase Lyk
Molecular Weight
Mass (kDA):
71.831 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 5q33.3 |
| Sequence: | 5; NC_000005.10 (157180840..157255185) |
Tissue Specificity
T-cell lines and natural killer cell lines.
Subcellular Localizations
Cytoplasm. Nucleus. Localizes in the vicinity of cell surface receptors in the plasma membrane after receptor stimulation.
Diseases
- Inflammation
- Asthma
- Agammaglobulinemia
- Tissue Adhesions
- Immunologic Deficiency Syndromes
- Allergic Asthma
- X-linked Agammaglobulinemia
- Malignant Neoplasms
- Lymphoma
- Neoplasms
- Leukemia
- Autoimmune Reaction
- T-cell Lymphoma
Interacting Proteins
- ERBB2
- FASLG
- HSP90AB1
- LCP2
Pathways
- Cell Activation
- T Cell Activation
- Secretion
- Cell Development
- Cytokine Production
- Localization
- Segmentation
- Cell Proliferation
- Immune Response
- Cytokine Secretion
- Cell Differentiation
- Pathogenesis
- Cell Adhesion
PTMs
- Phosphorylation
- Palmitoylation
- Cleavage
Research Areas
- Protein Kinase
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ITK
bosterbio.com/bosterbio-gene-info-cards/ITK
References
PMID: 8504851 by Tanaka N., et al. A novel human tyrosine kinase gene inducible in T cells by interleukin 2.
PMID: 8364206 by Gibson S., et al. Identification, cloning, and characterization of a novel human T- cell-specific tyrosine kinase located at the hematopoietin complex on chromosome 5q.