ITPR3 Antibodies

Inositol 1,4,5-trisphosphate receptor type 3 (ITPR3)

Receptor for inositol 1,4,5-trisphosphate, another messenger that mediates the release of intracellular calcium. .

Gene Information

Human
Gene Name:	ITPR3
Uniprot:	Q14573
Entrez:	3710

Family

Belongs to:
InsP3 receptor family

Alternative Names

FLJ36205; inositol 14,5-triphosphate receptor, type 3; inositol 14,5-trisphosphate receptor type 3; insP3R3; IP3 receptor isoform 3; IP3 receptor; IP3R 3; IP3R; IP3R3; Type 3 inositol 14,5-trisphosphate receptor; Type 3 InsP3 receptor

Molecular Weight

Mass (kDA):
304.106 kDA

Genomic Context

Human
Location:	6p21.31
Sequence:	6; NC_000006.12 (33621322..33696562)

Tissue Specificity

Expressed in intestinal crypt and villus epithelial cells.

Subcellular Localizations

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Diseases

• Diabetes Mellitus
• Diabetes Mellitus, Insulin-dependent
• Lupus Erythematosus, Systemic
• Rheumatoid Arthritis
• Dysequilibrium Syndrome
• Graves Disease
• Autoimmune Diseases
• Arthritis
• Autoimmune Reaction
• Aneurysm
• Neoplasm Metastasis
• Cardiac Arrhythmia
• Metastatic Malignant Neoplasm To The Lymph Node

• Metastatic Malignant Neoplasm To The Liver
• Colonic Neoplasms
• Malignant Tumor Of Colon
• Carcinoma
• Carcinogenesis
• Mucocutaneous Lymph Node Syndrome
• Malignant Neoplasms

Interacting Proteins

• BAP1
• TRPC3

Pathways

• Localization
• Secretion
• Cell Proliferation
• Insulin Secretion
• Dna Repair
• Rna Splicing
• Cell Division
• Tissue Development
• Hair Cycle
• Phagocytosis

• Anagen
• Telogen
• Rna Processing
• Pathogenesis

PTMs

• Phosphoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ITPR3

Boster Bio - Best Uses Of The ITPR3 Marker

If you are in search of primary antibodies, then you've come to the right place! Boster Bio offers high-affinity primary antibodies to the ITPR3 Marker. Learn more about Boster's ITPR3 Marker. Find out how you can optimize Boster’s antibodies and troubleshoot workflow. We hope that this article will aid you in your research!

Boster Bio offers high-affinity primary antibodies

A variety of biotech companies have produced primary antibodies to the ITPR3 marker However, only Boster Bio has produced an antibody that is specific to this protein. The ITPR3 marker is found in a wide variety of proteins and may be found in a vast range of cell types including human. This antibody is a binder to protein A (IgG) and protein G (IgG4).

Boster's ITPR3 Marker

A study of the expression levels of Boster's ITPR3 was conducted in bladder cancer tissues and cells. It was found that ITPR3 regulates NFKB/CD44 and contributes to the development of bladder cancer. The findings were based upon biochemistry and molecular biology techniques such as flow cytometry and the MTT assay and the xenograft tumor model. Further studies will confirm the clinical value of ITPR3 as a determinant in bladder cancer.

ITPRs are common Ca2+ channels that are found in the endoplasmicreticulum (ER). These proteins interact with GRP75 and accelerate the transmission of calcium in cells. These proteins play a significant role in controlling numerous functions in the cell, such as cell migration and the growth of tumors. ITPR3 is the largest of all ITPRs; ITPR1 and ITPR2 are responsible for the remaining 10 percent. The precise mechanisms through ITPR3 play an oncogenic function in cancer remain elusive.

To confirm the findings, the RNA from BCa cells was isolated and reverse-transcribed into complementary DNA (cDNA) to confirm their. To detect cDNA it was the Takara Bio Dalian (China) Prime RTPCR kit from Takara Bio Dalian (China) was used. To determine the expression of genes, cDNA is amplified by using SYBR Green Master Mix. The primers used for detecting gene expression included ITPR1 primer followed by ITPR2 primer and 18S primer.

In addition to identifying the methylation status, BSP also examined the levels of ITPR3 in normal bladder cells. BSP correctly predicted three CpG islands of more than 200 bp in ITPR3's promoter region. BSP also showed the status of ITPR3's methylation was not positively correlated with the levels of mRNA in bladder cancer. If these findings are confirmed that is, the BSP can be a valuable tool for bladder cancer diagnosis.