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- Table of Contents
IL27 Antibodies
AND IL27 ELISA kits, IL27 Proteins
Many biological assays use antibodies to detect IL27, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with IL27 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop IL27 antibodies...
Designing a Western blot for IL27? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the IL27 Western Blot GuideIL27 Infographic by Boster Bio
All IL27 Products
Product
Figures
Specificity
Applications
Price
Mouse
ELISA
$500
Cat # EZ0800
For 5 plates, 96 wells each, reagents only, plates are not included
Cat # EZ0800
For 5 plates, 96 wells each, reagents only, plates are not included
Mouse
ELISA
$499
Cat # EK0800
96 wells/kit, with removable strips.
Cat # EK0800
96 wells/kit, with removable strips.
Human, Mouse, Rat
ELISA, IF, IHC-P, WB
$481
Cat # A07190-1
0.1 mg
Cat # A07190-1
0.1 mg
Mouse
Cell Culture
$77
Cat # PROTQ8K3I6-1
5ug,20ug,100ug
Cat # PROTQ8K3I6-1
5ug,20ug,100ug
Human
Cell Culture
$77
Cat # PROTQ8NEV9-1
5ug,20ug,100ug
Cat # PROTQ8NEV9-1
5ug,20ug,100ug
IL27 Overview
Facts about Interleukin-27 subunit alpha.
Interleukin-27 subunit alpha (IL27)
Associates with EBI3 to form the IL-27 interleukin, a heterodimeric cytokine which functions in innate immunity. IL-27 has pro- and anti-inflammatory properties, which may regulate T- helper cell development, suppress T-cell proliferation, stimulate cytotoxic T-cell activity, induce isotype switching in B-cells, and that has diverse effects on innate immune cells.
Among its target cells are CD4 T-helper cells which can differentiate in type 1 effector cells (TH1), type 2 effector cells (TH2) and IL17 producing helper T-cells (TH17). It drives rapid clonal expansion of naive but not memory CD4 T-cells.
Gene Information
| Human | |
|---|---|
| Gene Name: | IL27 |
| Uniprot: | Q8NEV9 |
| Entrez: | 246778 |
Family
| Belongs to: |
|---|
| IL-6 superfamily |
Alternative Names
IL-27 p28 subunit; IL-27 subunit alpha; IL27; IL-27; IL27A; IL-27-A; IL27-A; IL27p28; IL30; interleukin 27; interleukin 30; interleukin-27 subunit alpha; MGC71873; p28IL-27A
Molecular Weight
Mass (kDA):
27.493 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 16p12.1-p11.2 |
| Sequence: | 16; NC_000016.10 (28499362..28526730, complement) |
Tissue Specificity
Expressed in monocytes and in placenta.
Subcellular Localizations
Secreted. Does not seem to be secreted without coexpression of EBI3.
Diseases
- Inflammation
- Autoimmune Reaction
- Autoimmune Diseases
- Neoplasms
- Malignant Neoplasms
- Experimental Autoimmune Encephalomyelitis
- Encephalomyelitis
- Autoimmunity
- Carcinoma
- Crohn Disease
- Arthritis
- Rheumatoid Arthritis
Interacting Proteins
- EBI3
Pathways
- Secretion
- Immune Response
- Pathogenesis
- Cytokine Production
- Cell Differentiation
- Cell Proliferation
- Cell Activation
- Inflammatory Response
- T Cell Activation
- Hypersensitivity
- T Cell Proliferation
- Cell Development
- Angiogenesis
PTMs
- Phosphorylation
- Cleavage
- Glycosylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/IL27
bosterbio.com/bosterbio-gene-info-cards/IL27
References
PMID: 12121660 by Pflanz S., et al. IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4(+) T cells.
PMID: 14565860 by Hibbert L., et al. IL-27 and IFN-alpha signal via Stat1 and Stat3 and induce T-Bet and IL-12Rbeta2 in naive T cells.
2 Publications of Boster IL27 Antibodies & ELISA Kits
- PubMed ID: 23725508, Effect of interferon-? on NF-?B and cytokine IL-18 and IL-27 in acute pancreatit...
- PubMed ID: 29368801, Kumar VHS, Wang H, Nielsen L. Physiol Rep. 2018 Jan;6(2). doi: 10.14814/phy2.135...
*More publications can be found for each product on its corresponding product page