JAM2 Antibodies

Junctional adhesion molecule B (JAM2)

May play a role in the processes of lymphocyte homing to secondary lymphoid organs. .

Gene Information

Human
Gene Name:	JAM2
Uniprot:	P57087
Entrez:	58494

Family

Belongs to:
immunoglobulin superfamily

Alternative Names

C21orf43; CD322 antigen; CD322; JAM2; JAMB; JAM-B; JAM-BJAM-IT/VE-JAM; junctional adhesion molecule 2JAM-2; junctional adhesion molecule B; PRO245; Vascular endothelial junction-associated molecule; VE-JAM; VE-JAMVEJAMCD322

Molecular Weight

Mass (kDA):
33.207 kDA

Genomic Context

Human
Location:	21q21.3
Sequence:	21; NC_000021.9 (25607550..25717562)

Tissue Specificity

Highest expression in the heart, placenta, lung, foreskin and lymph node. Prominently expressed on high endothelial venules, also present on the endothelia of other vessels. Localized to the intercellular boundaries of high endothelial cells.

Subcellular Localizations

Cell membrane; Single-pass type I membrane protein. Cell junction. Cell junction, tight junction. Localized at tight junctions of both epithelial and endothelial cells (By similarity). Specifically localized within the somatodendritic compartment of neurons and excluded from the axon (By similarity).

Diseases

• Tissue Adhesions
• Neoplasms
• Malignant Neoplasms
• Inflammation
• Tumor Angiogenesis
• Extravasation
• Carcinoma
• Auricular Swelling
• Pathologic Neovascularization
• Malignant Paraganglionic Neoplasm
• Edema
• Sclerosis
• Adenoma

• Neoplasm Metastasis
• Dementia
• Glioma
• Down Syndrome
• Diffuse Scleroderma
• Mouth Neoplasms
• Gastric Adenocarcinoma

Interacting Proteins

• JAM3

Pathways

• Cell Adhesion
• Localization
• Angiogenesis
• Immune Response
• Lymphangiogenesis
• Transport
• Diapedesis
• Cell Proliferation
• Cell Migration
• Dna Methylation
• Glycosylation
• Platelet Activation
• Hypersensitivity

• Leukocyte Differentiation
• Establishment Of Epithelial Cell Polarity
• Methylation
• Regeneration
• Sensitization
• Cell Cycle
• Transdifferentiation

PTMs

• Phosphorylation
• Biotinylation

• Glycosylation
• Methylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/JAM2

Boster Bio: Best Uses Of The JAM2 Marker

If you're interested in learning more about Steven Boster, you've come to the right place. This biography will provide a detailed overview of Boster’s career, life and current projects. This biography will provide you with information about Boster's career, background, and current projects. Continue reading to learn more about Boster’s JAM2 Marker products.

Steven Boster

Scientists created the JAM2 marker to help identify diseases and their symptoms. The JAM2 marker is the most widely used to track the progression of COVID-19. It has been used since 1960s for the detection melanoma. It is best used by doctors to detect COVID-related tumors in the brain. The JAM2 works with the JAM2 protocol. It can be used by anyone suffering from MSK, a blood disorder, and any other gastrointestinal condition.

In addition to mapping the position of a disease, the JAM2 can be used to detect its presence in the body. Its radioactive nature allows it to be used to diagnose a disease in a person. It is a common disease that affects many people. It can be detected by listening to it on the radio. This can be done by knowing the frequency of the radio station.

Historie

The Historie for the JAM2 marker is part of JAM family of immunoglobulin-superfamily proteins. They have two immunoglobulin like domains, one of which is a transmembrane, and a tail cytoplasmic. JAM proteins are homo and heterodimerized with other Jam family members. Its function has been associated with T lymphopoiesis in the hematopoietic cells.

The JAM2 genes is a transcription element that can be expressed by a variety cells. The JAM2 gene is expressed by mesenchymal cells in ovarian cancer. In a recent study JAM2 expression was found to be correlated with patient prognosis. This was then further investigated in the context of ovarian and other cancers. The findings of this study point to the potential role of JAM2 in the maintenance of mesenchymal identity in the disease.

Career

The JAM2 Marker serves many purposes in biology. It has been shown to have prognostic and diagnostic capabilities in breast cancer. It can be used to diagnose and predict cancer using a variety of techniques such as RT qPCR (Wallaby blot), Western blot, scratch asay, and transwell assay. This gene expression has been shown to be strongly associated with various types of cancer such as melanoma.

Current projects

Current research on JAM2 has revealed a new function for JAM2 in lymphoid tissue. JAM2 expression is found on all human cells, as well as a subset if T cells, monocytes and B cells. This marker may regulate transmigration through multiple mechanisms that differ between human and mouse systems. Further research is needed to understand how JAM2 might be involved in these processes.

Two approaches were employed to study JAM2's role in ovarian and cervical cancer. First, a computational biology strategy was used to identify the common genes that were up-regulated in mesenchymal and non-mesenchymal ovarian cancer tissues. Next, the genes that corresponded to these proteins were discovered. Junctional adhesion protein 2 (JAM2) was the most closely associated with prognosis for patients suffering from ovarian cancer. Next, JAM2 had a functional role.

The JAM-2 sequence for human JAM-2 is homologous with murine DNA to a high degree. This homology opens up research opportunities to study the effects the JAM2 gene has on the human genetic code. Researchers use the human JAM-2 cDNA clone IMAGE in conjunction with the 5' coding sequence supplied by the Human Genome Mapping Project Resource Center HGMRRC in Paisley, United Kingdom.

Not only is miR330-3p associated with poor prognosis, but the JAM2 genetic mutation is also known to be associated. The identification of new therapeutic targets to the JAM2 protein is critical for improving ovarian treatment. This is a new field in which the JAM2 genes is being investigated. Many scientists are already researching it. Its potential role in ovarian carcinoma cells is very promising.