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- Table of Contents
Junction plakoglobin Antibodies
AND JUP ELISA kits, Junction plakoglobin Proteins
Many biological assays use antibodies to detect Junction plakoglobin, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Junction plakoglobin in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Junction plakoglobin antibodies...
Designing a Western blot for Junction plakoglobin? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the JUP Western Blot GuideJUP Infographic by Boster Bio
All JUP Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
Flow Cytometry, IF, IHC, IHC-F, ICC, WB
$370
Cat # PB9185
100 μg/vial
Cat # PB9185
100 μg/vial
Human, Mouse, Rat
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # M01901-3
100 μg/vial
Cat # M01901-3
100 μg/vial
Human
Flow Cytometry, IF, ICC, WB
$370
Cat # PA1117-1
100 μg/vial
Cat # PA1117-1
100 μg/vial
Human, Mouse, Rat
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # M01901-1
100 μl
Cat # M01901-1
100 μl
Human, Mouse, Rat
ELISA
$480
Cat # EKC1092
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1092
1 kit, containing one 96-well plate and all necessary reagents
JUP Overview
Facts about Junction plakoglobin.
Junction plakoglobin (JUP)
Common junctional plaque protein. The membrane- associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue.
The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE- cadherin function in endothelial cells.
Gene Information
| Human | |
|---|---|
| Gene Name: | JUP |
| Uniprot: | P14923 |
| Entrez: | 3728 |
Family
| Belongs to: |
|---|
| beta-catenin family |
Alternative Names
catenin (cadherin-associated protein), gamma (80kD); catenin (cadherin-associated protein), gamma 80kDa; Catenin gamma; Desmoplakin III; desmoplakin-3; DP3CTNNG; DPIII; gamma-catenin; junction plakoglobin; PDGBARVD12; PKGB
Molecular Weight
Mass (kDA):
81.745 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 17q21.2 |
| Sequence: | 17; NC_000017.11 (41754607..41786768, complement) |
Subcellular Localizations
Cell junction, adherens junction. Cell junction, desmosome. Cytoplasm, cytoskeleton. Membrane; Peripheral membrane protein. Cytoplasmic in a soluble and membrane-associated form.
Diseases
- Tissue Adhesions
- Neoplasms
- Malignant Neoplasms
- Carcinoma
- Neoplasm Metastasis
- Cardiomyopathies
- Cell Invasion
- Arrhythmogenic Right Ventricular Dysplasia
- Cell Transformation, Neoplastic
- Malignant Paraganglionic Neoplasm
- Malignant Squamous Cell Neoplasm
- Adenocarcinoma
- Malignant Neoplasm Of Breast
Interacting Proteins
- APC
- AXIN1
- CDH2
- CTNNA1
- CTNNB1
- CTNNBIP1
- FHL2
- PECAM1
- WDYHV1
Pathways
- Cell Adhesion
- Cell-cell Adhesion
- Localization
- Pathogenesis
- Cell Proliferation
- Methylation
- Cell Growth
- Cellular Localization
- Proteolysis
- Tissue Morphogenesis
- Cell Migration
- Cell Motility
- Epithelial Cell-cell Adhesion
PTMs
- Phosphorylation
- Cleavage
- Methylation
Research Areas
- Cancer
- Cell Biology
- Cellular Markers
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/JUP
bosterbio.com/bosterbio-gene-info-cards/JUP
References
PMID: 2726765 by Franke W.W., et al. Molecular cloning and amino acid sequence of human plakoglobin, the common junctional plaque protein.
PMID: 11016852 by Whittock N.V., et al. Genomic organization and amplification of the human plakoglobin gene (JUP).