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KCNJ5 Antibodies
AND KCNJ5 ELISA kits, KCNJ5 Proteins
Many biological assays use antibodies to detect KCNJ5, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with KCNJ5 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop KCNJ5 antibodies...
Designing an IHC experiment for KCNJ5? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the KCNJ5 IHC GuideKCNJ5 Infographic by Boster Bio
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KCNJ5 Overview
Facts about G protein-activated inward rectifier potassium channel 4.
G protein-activated inward rectifier potassium channel 4 (KCNJ5)
This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it.
Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium.
Gene Information
| Human | |
|---|---|
| Gene Name: | KCNJ5 |
| Uniprot: | P48544 |
| Entrez: | 3762 |
Family
| Belongs to: |
|---|
| inward rectifier-type potassium channel (TC 1.A.2.1) family |
Alternative Names
Cardiac inward rectifier; CIRKIR3.4; G protein-activated inward rectifier potassium channel 4; GIRK-4; GIRK4Kir3.4; Heart KATP channel; Inward rectifier K(+) channel Kir3.4; inward rectifier K+ channel KIR3.4; IRK-4; KATP-1; KATP1cardiac ATP-sensitive potassium channel; LQT13; Potassium channel, inwardly rectifying subfamily J member 5; potassium inwardly-rectifying channel, subfamily J, member 5
Molecular Weight
Mass (kDA):
47.668 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 11q24.3 |
| Sequence: | 11; NC_000011.10 (128891356..128921163) |
Tissue Specificity
Islets, exocrine pancreas and heart. Expressed in the adrenal cortex, particularly the zona glomerulosa.
Subcellular Localizations
Membrane; Multi-pass membrane protein.
Diseases
- Hyperaldosteronism
- Adenoma
- Conn Syndrome
- Hypertensive Disease
- Hyperplasia
- Neoplasms
- Tumors Of Adrenal Cortex
- Adrenal Gland Neoplasms
- Cardiac Fibrillation
- Cardiac Arrhythmia
- Adrenal Cortical Adenoma
- Infarction
- Myocardial Infarction
Pathways
- Pathogenesis
- Membrane Depolarization
- Cell Proliferation
- Secretion
- Aldosterone Secretion
- Insulin Secretion
- Transport
- Regulation Of Signaling
- Reverse Transcription
- Translation
- Nutrient Import
- Lipid Homeostasis
- Diestrus
PTMs
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/KCNJ5
bosterbio.com/bosterbio-gene-info-cards/KCNJ5
References
PMID: 8047164 by Ashford M.L.J., et al. Cloning and functional expression of a rat heart KATP channel.
PMID: 8558261 by Spauschus A., et al. A G-protein-activated inwardly rectifying K+ channel (GIRK4) from human hippocampus associates with other GIRK channels.