Protein TALPID3 Antibodies

AND KIAA0586 ELISA kits, Protein TALPID3 Proteins

Many biological assays use antibodies to detect Protein TALPID3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Protein TALPID3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Protein TALPID3 antibodies...

We validate the specificity of these antibodies to Protein TALPID3 by testing them on tissues known to express KIAA0586 positively and negatively. Browse below to find the KIAA0586 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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KIAA0586 Infographic by Boster Bio

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Anti-TALPID3 antibody

Human, Mouse

ELISA, IF, IHC, ICC

$370
Cat # A06960
100 μl/vial

KIAA0586 Overview

Facts about Protein TALPID3.

KIAA0586 3D structure. Source: alphafold

Protein TALPID3 (KIAA0586)

Required for ciliogenesis and sonic hedgehog/SHH signaling. Required for the centrosomal recruitment of RAB8A and for the targeting of centriole satellite proteins to centrosomes such as of PCM1.

May play a role in ancient ciliogenesis in the disappearance of centriolar satellites which preceeds ciliary vesicle formation (PubMed:24421332). Involved in regulation of cell intracellular organization.

Gene Information

Human
Gene Name:	KIAA0586
Uniprot:	Q9BVV6
Entrez:	9786

Family

Belongs to:

TALPID3 family

Alternative Names

Protein TALPID3

Molecular Weight

Mass (kDA):
169.307 kDA

Genomic Context


Human

Location:	14q23.1
Sequence:	14; NC_000014.9 (58427385..58551297)

Tissue Specificity

Ubiquitously expressed (PubMed:26386044). Expressed in photoreceptor cells (at protein level) (PubMed:26386247).

Subcellular Localizations

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Photoreceptor inner segment. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, cilium basal body. Forms a ring-like structure at the extreme distal end of both mother and daughter centrioles (PubMed:24421332). In photoreceptor cells localized to the joint between the inner and outer segments, specifically localized at the mother centriole (basal body) and the adjacent centriole as well as between the two centrioles but not in the connecting cilium (PubMed:26386247).

Diseases

Joubert syndrome 23 (JBTS23)

PTMs

Phosphoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/KIAA0586

References

PMID: 19144723 by Yin Y., et al. The Talpid3 gene (KIAA0586) encodes a centrosomal protein that is essential for primary cilia formation.

PMID: 24421332 by Kobayashi T., et al. The CP110-interacting proteins Talpid3 and Cep290 play overlapping and distinct roles in cilia assembly.