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KIF20B Antibodies
AND KIF20B ELISA kits, KIF20B Proteins
Many biological assays use antibodies to detect KIF20B, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with KIF20B in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop KIF20B antibodies...
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KIF20B Overview
Facts about Kinesin-like protein KIF20B.
Kinesin-like protein KIF20B (KIF20B)
Plus-end-directed motor enzyme that's required for completion of cytokinesis (PubMed:11470801, PubMed:12740395). Required for proper midbody organization and abscission in polarized cortical stem cells.
Plays a role in the regulation of neuronal polarization by mediating the transport of specific cargos. Participates in the mobilization of SHTN1 and in the accumulation of PIP3 in the growth cone of primary hippocampal neurons at a tubulin and actin-dependent method.
Gene Information
| Human | |
|---|---|
| Gene Name: | KIF20B |
| Uniprot: | Q96Q89 |
| Entrez: | 9585 |
Family
| Belongs to: |
|---|
| TRAFAC class myosin-kinesin ATPase superfamily |
Alternative Names
Cancer/testis antigen 90; CT90MPP-1; DKFZp434B0435; EC 6.3.5.5; kinesin family member 20B; Kinesin-related motor interacting with PIN1; KRMP1kinesin-like protein KIF20B; M-phase phosphoprotein 1mitotic kinesin-like protein; MPHOSPH1EC 2.1.1; MPP1DKFZp434P0810
Molecular Weight
Mass (kDA):
210.629 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 10q23.31 |
| Sequence: | 10; NC_000010.11 (89701590..89774943) |
Tissue Specificity
Brain, ovary, kidney and testis (at protein level) (PubMed:12740395). Overexpressed in bladder cancer cells (at protein level) (PubMed:17409436). Expressed in testis. Overexpressed in bladder cancer cells (PubMed:17409436).
Subcellular Localizations
Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus, nucleolus. Nucleus, nucleoplasm. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Midbody. Cell projection, axon. Cell projection, growth cone. Localizes mainly in the nucleus during interphase although it is also detected in the cytoplasm without clear association with microtubules (PubMed:12740395). Localized to the central spindle during cytokinetic furrowing and with the midbody during abscission (PubMed:12740395, PubMed:17409436). A 2-3 fold expression increase is seen as cells pr
Diseases
- Malignant Neoplasms
- Neoplasms
- Ataxia
- Malignant Neoplasm Of Urinary Bladder
- Adenocarcinoma
- Bladder Neoplasm
- Sclerosis
- Adenoma
- Primary Lateral Sclerosis
- Polyneuropathy
- Malignant Neoplasm Of Breast
- Glioma
Pathways
- Mitosis
- Interphase
- Cell Death
- M Phase
- Cytokinesis
- Cell Cycle
- Pathogenesis
- Centromere Separation
- Programmed Cell Death
- Induction Of Apoptosis
- Fertilization
- Metaphase
- Insemination
PTMs
- Phosphorylation
Research Areas
- Cell Cycle and Replication
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/KIF20B
bosterbio.com/bosterbio-gene-info-cards/KIF20B
References
PMID: 11470801 by Kamimoto T., et al. Identification of a novel kinesin-related protein, KRMP1, as a target for mitotic peptidyl-prolyl isomerase Pin1.
PMID: 12740395 by Abaza A., et al. M phase phosphoprotein 1 is a human plus-end-directed kinesin-related protein required for cytokinesis.