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- Table of Contents
KIF2C Antibodies
AND KIF2C ELISA kits, KIF2C Proteins
Many biological assays use antibodies to detect KIF2C, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with KIF2C in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop KIF2C antibodies...
Designing a Western blot for KIF2C? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the KIF2C Western Blot GuideDesigning an IHC experiment for KIF2C? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the KIF2C IHC GuideKIF2C Infographic by Boster Bio
All KIF2C Products
Product
Figures
Specificity
Applications
Price
Anti-MCAK/KIF2C Antibody Picoband®
1 Citations
Human, Mouse, Rat
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # PB9230
100 μg/vial
Cat # PB9230
100 μg/vial
Human
Flow Cytometry, IF, ICC, WB
$370
Cat # M03202-1
100 μl/vial
Cat # M03202-1
100 μl/vial
KIF2C Overview
Facts about Kinesin-like protein KIF2C.
Kinesin-like protein KIF2C (KIF2C)
In complex with KIF18B, constitutes the significant microtubule plus-end depolymerizing activity in mitotic cells (PubMed:21820309). Regulates the turnover of microtubules in the kinetochore and functions in chromosome segregation during mitosis (PubMed:19060894).
Plays a role in chromosome congression and is required for the lateral to end-on conversion of the chromosome- microtubule attachment (PubMed:23891108). .
Gene Information
| Human | |
|---|---|
| Gene Name: | KIF2C |
| Uniprot: | Q99661 |
| Entrez: | 11004 |
Family
| Belongs to: |
|---|
| TRAFAC class myosin-kinesin ATPase superfamily |
Alternative Names
kinesin family member 2C; kinesin-like 6 (mitotic centromere-associated kinesin); Kinesin-like protein 6; kinesin-like protein KIF2C; MCAKKNSL6kinesin-like 6; Mitotic centromere-associated kinesin
Molecular Weight
Mass (kDA):
81.313 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 1p34.1 |
| Sequence: | 1; NC_000001.11 (44739704..44767767) |
Tissue Specificity
Expressed at high levels in thymus and testis, at low levels in small intestine, the mucosal lining of colon, and placenta, and at very low levels in spleen and ovary; expression is not detected in prostate, peripheral blood Leukocytes, heart, brain, lung, liver, skeletal muscle, kidney or pancreas. Isoform 2 is testis-specific.
Subcellular Localizations
Cytoplasm, cytoskeleton. Nucleus. Chromosome, centromere. Chromosome, centromere, kinetochore. Associates with the microtubule network at the growing distal tip (the plus-end) of microtubules, probably through interaction with MTUS2/TIP150 and MAPRE1 (By similarity). Association with microtubule plus ends is also mediated by interaction with KIF18B. Centromeric localization requires the presence of BUB1 and SGO2.
Diseases
- Malignant Neoplasms
- Neoplasms
- Malignant Neoplasm Of Breast
- Aneuploidy
- Mammary Neoplasms
- Neoplasm Metastasis
- Carcinoma
- Malignant Paraganglionic Neoplasm
- Cell Transformation, Neoplastic
- Metastatic Malignant Neoplasm To The Lymph Node
- Genomic Instability
- Colorectal Neoplasms
- Carcinogenesis
Interacting Proteins
- MAPRE1
- MTUS2
Pathways
- Mitosis
- Chromosome Segregation
- Spindle Assembly
- Localization
- Cell Cycle
- Anaphase
- Metaphase
- Cell Division
- Microtubule Depolymerization
- Interphase
- Cytokinesis
- Prophase
- Meiosis
PTMs
- Phosphorylation
- Cleavage
Research Areas
- Cancer
- Cell Biology
- Cellular Markers
- DNA Repair
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/KIF2C
bosterbio.com/bosterbio-gene-info-cards/KIF2C
References
PMID: 9434124 by Kim I.-G., et al. Cloning and expression of human mitotic centromere-associated kinesin gene.
PMID: 12383881 by Cheng L.J., et al. Expression of a novel HsMCAK mRNA splice variant, tsMCAK gene, in human testis.