Beta-klotho Antibodies

AND Klb ELISA kits, Beta-klotho Proteins

Many biological assays use antibodies to detect Beta-klotho, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Beta-klotho in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Beta-klotho antibodies...

We validate the specificity of these antibodies to Beta-klotho by testing them on tissues known to express Klb positively and negatively. Browse below to find the Klb antibody that suites your experiment. We have 4 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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Klb Infographic by Boster Bio

All Klb Products

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Applications

Price

Human Klotho beta/KLB ELISA Kit PicoKine®

2 Citations 8 Q&As

Human

ELISA

$750
Cat # EK1492
96 wells/kit, with removable strips.

Anti-KLOTB KLB Antibody

Human, Mouse

ELISA, WB

$380
Cat # A05877
100ul

Anti-Klotho Beta Reference Antibody (NGM313)

The purity of Anti-Klotho Beta Reference Antibody (NGM313)is more than 95%

Cynomolgus monkey, Human, Mouse

ELISA, Flow Cytometry, Functional Assay, Kinetics

$486
Cat # M05877
100 μg

Anti-Klotho Beta Reference Antibody (RG7992)

The purity of Anti-Klotho Beta Reference Antibody (RG7992)is more than 95

Cynomolgus monkey, Human, Mouse, Rabbit, Rat

ELISA, Flow Cytometry, Functional Assay, Kinetics

$486
Cat # M05877-1
100 μg

Klb Overview

Facts about Beta-klotho.

Beta-klotho (Klb)

Contributes to the transcriptional repression of cholesterol 7-alpha-hydroxylase (CYP7A1), the rate-limiting enzyme in bile acid synthesis. Probably inactive as a glycosidase.

Increases the ability of FGFR1 and FGFR4 to bind FGF21. .

Gene Information

Mouse
Gene Name:	Klb
Uniprot:	Q99N32
Entrez:	83379

Family

Belongs to:

glycosyl hydrolase 1 family

Alternative Names

betaKlotho; beta-klotho; BKL; KLB; klotho beta like; Klotho beta; klotho beta-like protein; MGC142213

Molecular Weight

Mass (kDA):
120.189 kDA

Genomic Context


Mouse

Location:	5\|5 C3.1
Sequence:	5;

Tissue Specificity

Present in liver, muscle and white adipose tissue, but not in kidney (at protein level). Expressed in liver and pancreas, and at lower levels in skin, stomach, skeletal muscle, small intestine and lung.

Diseases

Obesity
Irritable Bowel Syndrome
Insulin Resistance
Neoplasms
Diarrhea
Irritable Bowel Syndrome With Diarrhea
Cholecystolithiasis
Malabsorption Syndrome
Cholangiocarcinoma
Carcinoma
Malignant Neoplasms
Liver Carcinoma
Insulin Sensitivity

Inflammation
Stasis
Dyslipidemias
Infarction
Malignant Tumor Of Colon
Premature Aging Syndrome
Constipation

Pathways

Cell Proliferation
Glucose Homeostasis
Gallstone Formation
Energy Homeostasis
Regulation Of Glucose Homeostasis
Excretion
Cellular Homeostasis
Entner-doudoroff Pathway
Aging
Hepatocyte Proliferation
Chondrocyte Proliferation

Senescence
Drug Resistance
Translation
Cell Death
Pathogenesis
Secretion

PTMs

Phosphorylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Klb

References

PMID: 11044614 by Ito S., et al. Molecular cloning and expression analyses of mouse betaklotho, which encodes a novel Klotho family protein.

PMID: 16075061 by Ito S., et al. Impaired negative feedback suppression of bile acid synthesis in mice lacking betaKlotho.

2 Publications of Boster Beta-klotho Antibodies & ELISA Kits

PubMed ID: 10.5114/aoms.2017.72424, Evaluation of FGF-19 and β-klotho as biomarkers in patients with intrahepatic c...
PubMed ID: 30697260, Evaluation of FGF-19 and β-klotho as biomarkers in patients with intrahepatic c...

*More publications can be found for each product on its corresponding product page