Kelch-like protein 25 Antibodies

AND KLHL25 ELISA kits, Kelch-like protein 25 Proteins

Many biological assays use antibodies to detect Kelch-like protein 25, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Kelch-like protein 25 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Kelch-like protein 25 antibodies...

We validate the specificity of these antibodies to Kelch-like protein 25 by testing them on tissues known to express KLHL25 positively and negatively. Browse below to find the KLHL25 antibody that suites your experiment. We have 4 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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KLHL25 Infographic by Boster Bio

All KLHL25 Products

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Specificity

Applications

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Anti-ENC-2 KLHL25 Antibody

Western blot analysis of ENC-2 in Jurkat cell lysate with ENC-2 antibody at 1 μg/mL in (A) the absence and (B) the presence of blocking peptide

Immunocytochemistry of ENC-2 in Jurkat cells with ENC-2 antibody at 5 μg/mL

Immunofluorescence of ENC-2 in Jurkat cells with ENC-2 antibody at 20 μg/mL

Human

ELISA, IF, ICC, WB

$481
Cat # A14745
0.1 mg

Anti-Kelch-like protein 25 KLHL25 Monoclonal Antibody

Western Blot analysis using KLHL25 Monoclonal Antibody against KLHL25-hIgGFc transfected HEK293 cell

Human

ELISA, WB

$380
Cat # M14745
100ul

KLHL25 (NM_022480) Human Over-expression Lysate

Human

$628
Cat # LS064410
20 µg, 100 µg

Anti-KLHL25 Antibody

Human, Mouse

ELISA, IF, IHC, ICC, WB

$370
Cat # A14745-1
100 μl/vial

KLHL25 Overview

Facts about Kelch-like protein 25.

KLHL25 3D structure. Source: alphafold

Kelch-like protein 25 (KLHL25)

Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1): ubiquitination and subsequent degradation of hypophosphorylated EIF4EBP1 (4E-BP1) probably serves as a homeostatic mechanism to maintain translation and protect against eIF4E inhibition when eIF4E levels are low.

The BCR(KLHL25) complex does not target EIF4EBP1 (4E-BP1) when it is hyperphosphorylated or associated with eIF4E. .

Gene Information

Human
Gene Name:	KLHL25
Uniprot:	Q9H0H3
Entrez:	64410

Family

Belongs to:

No superfamily

Alternative Names

ectodermal-neural cortex 2; ENC-2BTB/POZ KELCH domain protein; ENC2ectoderm-neural cortex protein 2; FLJ12587; FLJ45015; kelch-like 25 (Drosophila); Kelch-like protein 25

Molecular Weight

Mass (kDA):
65.923 kDA

Genomic Context


Human

Location:	15q25.3
Sequence:	15; NC_000015.10 (85759326..85794925, complement)

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/KLHL25

References

PMID: 22578813 by Yanagiya A., et al. Translational homeostasis via the mRNA cap-binding protein, eIF4E.