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- Table of Contents
KMO Antibodies
AND KMO ELISA kits, KMO Proteins
Many biological assays use antibodies to detect KMO, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with KMO in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop KMO antibodies...
Designing a Western blot for KMO? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the KMO Western Blot GuideDesigning an IHC experiment for KMO? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the KMO IHC GuideKMO Infographic by Boster Bio
All KMO Products
Product
Figures
Specificity
Applications
Price
Anti-KMO Antibody Picoband®
1 Citations
Human, Mouse, Rat
ELISA, Flow Cytometry, IHC, WB
$370
Cat # A05469-3
100 μg/vial
Cat # A05469-3
100 μg/vial
Human
$960
Cat # LS008564
20 µg, 100 µg
Cat # LS008564
20 µg, 100 µg
KMO Overview
Facts about Kynurenine 3-monooxygenase.
Kynurenine 3-monooxygenase (KMO)
Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn) (PubMed:29429898, PubMed:23575632, PubMed:26752518, PubMed:28604669, PubMed:29208702). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development.
Quinolinic acid may also have an effect on NMDA receptor signaling in pancreatic beta cells, osteoblasts, pancreatic cells, and the gastrointestinal tract (Probable). .
Gene Information
| Human | |
|---|---|
| Gene Name: | KMO |
| Uniprot: | O15229 |
| Entrez: | 8564 |
Family
| Belongs to: |
|---|
| aromatic-ring hydroxylase family |
Alternative Names
KMO; kynurenine 3-monooxygenase (kynurenine 3-hydroxylase); Kynurenine 3Monooxygenase; Kynurenine 3-Monooxygenase
Molecular Weight
Mass (kDA):
55.81 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 1q43 |
| Sequence: | 1; NC_000001.11 (241531883..241595642) |
Tissue Specificity
Highest levels in placenta and liver. Detectable in kidney.
Subcellular Localizations
Mitochondrion outer membrane; Multi-pass membrane protein.
Diseases
- Neurodegenerative Disorders
- Nerve Degeneration
- Depressive Disorder
- Schizophrenia
- Malignant Neoplasms
- Inflammation
- Huntington Disease
- Major Depressive Disorder
- Brain Ischemia
- Malignant Tumor Of Colon
- Ischemia
- Diabetes Mellitus
- Diabetes Mellitus, Non-insulin-dependent
Pathways
- Neuroprotection
- Cell Death
- Pathogenesis
- Circadian Rhythm
- Rumination
- Neurogenesis
- Menopause
- Neuron Death
- Localization
- Mismatch Repair
PTMs
- Hydroxylation
Research Areas
- Apoptosis
- Neurodegeneration
- Neuroscience
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/KMO
bosterbio.com/bosterbio-gene-info-cards/KMO
References
PMID: 9237672 by Alberati-Giani D., et al. Cloning and functional expression of human kynurenine 3- monooxygenase.
PMID: 10672018 by Breton J., et al. Functional characterization and mechanism of action of recombinant human kynurenine 3-hydroxylase.