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KMT2E Antibodies
AND KMT2E ELISA kits, KMT2E Proteins
Many biological assays use antibodies to detect KMT2E, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with KMT2E in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop KMT2E antibodies...
Designing an IHC experiment for KMT2E? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the KMT2E IHC GuideKMT2E Infographic by Boster Bio
All KMT2E Products
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KMT2E Overview
Facts about Inactive histone-lysine N-methyltransferase 2E.
Inactive histone-lysine N-methyltransferase 2E (KMT2E)
Associates with chromatin regions downstream of transcriptional start sites of genes that are active and so regulates gene transcription (PubMed:23629655, PubMed:24130829, PubMed:23798402). Chromatin interaction is mediated via the binding to tri-methylated histone H3 in'Lys-4' (H3K4me3) (PubMed:24130829, PubMed:23798402).
Key regulator of hematopoiesis involved with terminal myeloid differentiation and in the regulation of hematopoietic stem cell (HSCs) self-renewal by a mechanism which involves DNA methylation (By similarity). Also functions as an important cell cycle regulator, engaging in cell cycle regulatory system machinery at multiple cell cycle stages including G1/S transition, S phase progression and mitotic entry (PubMed:14718661, PubMed:18573682, PubMed:19264965, PubMed:23629655).
Gene Information
| Human | |
|---|---|
| Gene Name: | KMT2E |
| Uniprot: | Q8IZD2 |
| Entrez: | 55904 |
Family
| Belongs to: |
|---|
| class V-like SAM-binding methyltransferase superfamily |
Alternative Names
Inactive histone-lysine N-methyltransferase 2E
Molecular Weight
Mass (kDA):
204.965 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 7q22.3 |
| Sequence: | 7; NC_000007.14 (104940949..105115019) |
Tissue Specificity
Widely expressed in both adult and fetal tissues (PubMed:12101424, PubMed:23958951). Highest levels of expression observed in fetal thymus and kidney and in adult hematopoietic tissues, jejunum and cerebellum (PubMed:12101424, PubMed:23958951). Isoform NKp44L: Not detected on circulating cells from healthy individuals, but is expressed on a large panel of tumor and transformed cells (PubMed:23958951).
Subcellular Localizations
Chromosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus speckle. Absent from the nucleolus (PubMed:14718661). Localizes to chromosome during interphase and to centrosomes during mitosis (PubMed:23798402). Dissociation from mitotic chromosome is likely due to histone H3 phosphorylation on 'Thr-3' and 'Thr-6' (PubMed:23798402).; [Isoform 3]: Nucleus, nucleoplasm. Nucleus speckle. Absent from the nucleolus (PubMed:23629655). Localizes to chromosome during interphase and to nucleus speckle during mitosis (PubMed:23798402). Dissociation from mitotic chromosome is lik
Interacting Proteins
- NCR2
- TP53
PTMs
- Glycoprotein
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/KMT2E
bosterbio.com/bosterbio-gene-info-cards/KMT2E
References
PMID: 12101424 by Emerling B.M., et al. MLL5, a homolog of Drosophila trithorax located within a segment of chromosome band 7q22 implicated in myeloid leukemia.
PMID: 23958951 by Baychelier F., et al. Identification of a cellular ligand for the natural cytotoxicity receptor NKp44.