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- Table of Contents
LAMP3 Antibodies
AND LAMP3 ELISA kits, LAMP3 Proteins
Many biological assays use antibodies to detect LAMP3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with LAMP3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop LAMP3 antibodies...
Designing an IHC experiment for LAMP3? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the LAMP3 IHC GuideLAMP3 Infographic by Boster Bio
All LAMP3 Products
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LAMP3 Overview
Facts about Lysosome-associated membrane glycoprotein 3.
Lysosome-associated membrane glycoprotein 3 (LAMP3)
May play a role in dendritic cell function and in adaptive immunity. .
Gene Information
| Human | |
|---|---|
| Gene Name: | LAMP3 |
| Uniprot: | Q9UQV4 |
| Entrez: | 27074 |
Family
| Belongs to: |
|---|
| LAMP family |
Alternative Names
CD208 antigen; CD208; DCLAMP; DC-LAMP; DCLAMPDC-lysosome-associated membrane glycoprotein; LAMP; LAMP3; LAMP-3; lysosomal-associated membrane protein 3DC LAMP; lysosome-associated membrane glycoprotein 3; Protein TSC403; TSC403; TSC403CD208
Molecular Weight
Mass (kDA):
44.346 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 3q27.1 |
| Sequence: | 3; NC_000003.12 (183122215..183162761, complement) |
Tissue Specificity
Detected in tonsil interdigitating dendritic cells, in spleen, lymph node, Peyer's patches in the small instestine, in thymus medulla and in B-cells (at protein level). Expressed in lymphoid organs and dendritic cells. Expressed in lung. Up-regulated in carcinomas of the esophagus, colon, rectum, ureter, stomach, breast, fallopian tube, thyroid and parotid tissues.
Subcellular Localizations
Lysosome membrane; Single-pass type I membrane protein. Cytoplasmic vesicle membrane; Single-pass type I membrane protein. During dendritic cell maturation, detected on cytoplasmic vesicles (the MHC II compartment) that contain MHC II proteins, LAMP1, LAMP2 and LAMP3 (PubMed:9768752). Detected on lysosomes in mature dendritic cells (PubMed:9768752).
Diseases
- Malignant Neoplasms
- Neoplasms
- Neoplasm Metastasis
- Parkinson Disease
- Mammary Neoplasms
- Adenocarcinoma
- Malignant Neoplasm Of Breast
- Lung Neoplasms
- Pulmonary Fibrosis
- Autoimmunity
- Hypoxia
- Lung Diseases
- Malignant Tumor Of Cervix
Pathways
- Localization
- Transport
- Pathogenesis
- Secretion
- Translation
- Cell Cycle
- Cytokine Production
- Cell Adhesion
- Aging
- Immune Response
- Platelet Activation
- Transcytosis
- Tropism
PTMs
- Phosphorylation
- Cleavage
Research Areas
- Dendritic Cell Markers
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/LAMP3
bosterbio.com/bosterbio-gene-info-cards/LAMP3
References
PMID: 9721848 by Ozaki K., et al. Isolation and characterization of a novel human lung-specific gene homologous to lysosomal membrane glycoprotein 1 and 2; significantly increased expression in cancers of various tissues.
PMID: 9768752 by de Saint-Vis B.M., et al. A novel lysosome-associated membrane glycoprotein, DC-LAMP, induced upon DC maturation, is transiently expressed in MHC class II compartment.