Ragulator complex protein LAMTOR3 (LAMTOR3)

Included in the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag.

Activated Ragulator and Rag GTPases function as a scaffold recruitment mTORC1 to lysosomes where it is in turn triggered. Adapter protein that enhances the efficacy of the MAP kinase cascade facilitating the activation of MAPK2.