LARGE xylosyl- and glucuronyltransferase 2 (LARGE2)

Bifunctional glycosyltransferase with both xylosyltransferase and beta-1,3-glucuronyltransferase activities involved in the biosynthesis of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N-acetylglucosamine- beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1). Phosphorylated O-mannosyl trisaccharid is required for binding laminin G-like domain-containing extracellular proteins with high affinity.

Elongates the glucuronyl-beta-1,4-xylose-beta disaccharide primer arrangement by adding repeating units [-3-Xylose-alpha-1,3-GlcA-beta-1-] to generate a heteropolysaccharide. Has a higher activity toward alpha-dystroglycan than LARGE.