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- Table of Contents
LDLR Antibodies
AND LDLR ELISA kits, LDLR Proteins
Many biological assays use antibodies to detect LDLR, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with LDLR in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop LDLR antibodies...
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LDLR Infographic by Boster Bio
All LDLR Products
Product
Figures
Specificity
Applications
Price
Human LDLR ELISA Kit PicoKine®
10 Q&As
Human
ELISA
$499
Cat # EK1542
96 wells/kit, with removable strips.
Cat # EK1542
96 wells/kit, with removable strips.
Mouse
ELISA
$499
Cat # EK1543
96 wells/kit, with removable strips.
Cat # EK1543
96 wells/kit, with removable strips.
Anti-LDL Receptor/LDLR Antibody Picoband®
2 Citations
Human, Rat
ELISA, Flow Cytometry, IHC, WB
$370
Cat # A00076-2
100 μg/vial
Cat # A00076-2
100 μg/vial
LDLR Overview
Facts about Low-density lipoprotein receptor.
Low-density lipoprotein receptor (LDLR)
Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. So as to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits.
.
Gene Information
| Human | |
|---|---|
| Gene Name: | LDLR |
| Uniprot: | P01130 |
| Entrez: | 3949 |
Family
| Belongs to: |
|---|
| LDLR family |
Alternative Names
FH; FHC; LDL R; LDL receptor; LDLCQ2; LDLR; low density lipoprotein receptor; low-density lipoprotein receptor class A domain-containing protein 3; low-density lipoprotein receptor
Molecular Weight
Mass (kDA):
95.376 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 19p13.2 |
| Sequence: | 19; NC_000019.10 (11089432..11133820) |
Subcellular Localizations
Cell membrane; Single-pass type I membrane protein. Membrane, clathrin-coated pit. Golgi apparatus. Early endosome. Late endosome. Lysosome. Rapidly endocytosed upon ligand binding.
Diseases
- Hypercholesterolemia
- Atherosclerosis
- Hypercholesterolemia, Familial
- Hyperlipoproteinemia Type Iib
- Hyperlipidemia
- Arteriosclerosis
- Inflammation
- Cardiovascular Diseases
- Heart Diseases
- Coronary Heart Disease
- Dental Plaque
- Coronary Artery Disease
Interacting Proteins
- APOB
- APOE
- APOH
- Ldlrap1
- LRPAP1
- PCSK9
Pathways
- Transport
- Cholesterol Homeostasis
- Endocytosis
- Secretion
- Pathogenesis
- Cholesterol Efflux
- Localization
- Cell Adhesion
- Excretion
- Cholesterol Transport
- Inflammatory Response
- Translation
- Lipid Transport
PTMs
- Phosphorylation
- Cleavage
- Oxidation
- Ubiquitination
- Reduction
- Biotinylation
- Acetylation
- Methylation
- Carboxylation
- Glycosylation
Research Areas
- Cancer
- Cholesterol Metabolism
- Lipid and Metabolism
- Signal Transduction
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/LDLR
bosterbio.com/bosterbio-gene-info-cards/LDLR
References
PMID: 6091915 by Yamamoto T., et al. The human LDL receptor: a cysteine-rich protein with multiple Alu sequences in its mRNA.
PMID: 2988123 by Suedhof T.C., et al. The LDL receptor gene: a mosaic of exons shared with different proteins.
3 Publications of Boster LDLR Antibodies & ELISA Kits
- PubMed ID: 10.1007/s10753-013-9769-x, Difference in LDL Receptor Feedback Regulation in Macrophages and Vascular Smoot...
- PubMed ID: 10.1007/s00011-009-0052-4, Inflammatory stress increases unmodified LDL uptake via LDL receptor: an alterna...
- PubMed ID: 34151999, Zha K,Ye Q.Golgi a-mannosidase II mediates the formation of vascular smooth musc...
*More publications can be found for each product on its corresponding product page