LIAS Antibodies

AND LIAS ELISA kits, LIAS Proteins

Many biological assays use antibodies to detect LIAS, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with LIAS in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop LIAS antibodies...

We validate the specificity of these antibodies to LIAS by testing them on tissues known to express LIAS positively and negatively. Browse below to find the LIAS antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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LIAS Infographic by Boster Bio

All LIAS Products

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Figures

Specificity

Applications

Price

LIAS (NM_006859) Human Over-expression Lysate

Human

$628
Cat # LS011019
20 µg, 100 µg

Anti-LIAS antibody

IHC analysis of LIAS using anti-LIAS antibody (A08974-1)

Human, Mouse, Rat

ELISA, IHC, WB

$370
Cat # A08974-1
100 μl/vial

LIAS Overview

Facts about Lipoyl synthase, mitochondrial.

LIAS 3D structure. Source: alphafold

Lipoyl synthase, mitochondrial (LIAS)

Catalyzes the radical-mediated insertion of two sulfur atoms to the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. .

Gene Information

Human
Gene Name:	LIAS
Uniprot:	O43766
Entrez:	11019

Family

Belongs to:

radical SAM superfamily

Alternative Names

EC 2.8.1.8; LASmitochondrial; LIP1; lipoic acid synthetase; Lip-syn; MGC23245

Molecular Weight

Mass (kDA):
41.911 kDA

Genomic Context


Human

Location:	4p14
Sequence:	4; NC_000004.12 (39459024..39479506)

Subcellular Localizations

Mitochondrion.

Diseases

Diabetes Mellitus
Dental Caries
Atherosclerosis
Diabetic Nephropathy
Diabetes Mellitus, Experimental
Dental Plaque
Streptococcal Infections
Kidney Diseases
Dyslipidemias
Swine Vesicular Disease
Brain Ischemia
Diabetic Neuropathies

Immunologic Deficiency Syndromes
Hemorrhage
Hyperlipidemia
Flatulence
Microcephaly
Acidosis
Physiological Stress

Pathways

Virulence
Biofilm Formation
Pathogenesis
Sensitization
Hypersensitivity
Forebrain Development

Fatty Acid Oxidation

PTMs

Reduction

Oxidation

Phosphorylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/LIAS

References

PMID: 11124703 by Stanchi F., et al. Characterization of 16 novel human genes showing high similarity to yeast sequences.

PMID: 22152680 by Mayr J.A., et al. Lipoic acid synthetase deficiency causes neonatal-onset epilepsy, defective mitochondrial energy metabolism, and glycine elevation.