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We validate the specificity of these antibodies to DNA ligase 3 by testing them on tissues known to express LIG3 positively and negatively. Browse below to find the LIG3 antibody that suites your experiment. We have 4 of these antibodies and many publications and validation images.
If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.
Facts about DNA ligase 3.
|ATP-dependent DNA ligase family|
DNA ligase 3; DNA ligase III; EC 188.8.131.52; LIG2; ligase II, DNA, ATP-dependent; ligase III, DNA, ATP-dependent; Polydeoxyribonucleotide synthase [ATP] 3
|Sequence:||17; NC_000017.11 (34980498..35009743)|
Testis, thymus, prostate and heart.
[Isoform 1]: Mitochondrion. Contains an N-terminal mitochondrial transit peptide.; [Isoform 2]: Mitochondrion. Contains an N-terminal mitochondrial transit peptide.; [Isoform 3]: Nucleus. Lacks the N-terminal mitochondrial transit peptide.; [Isoform 4]: Nucleus. Lacks the N-terminal mitochondrial transit peptide.
This article will cover the many benefits and costs of the Boster Bio LIG3Marker. It also explains some of its most common uses. Continue reading to learn more about this marker and make an informed decision about its suitability for your research. Here are some examples of the benefits and common uses of this marker. You can also learn more about the application options, and answer common questions about this marker. Let's get started!
The LIG3 marker is a genetic marker that detects the presence of the gene LIG3. It is a protein essential for the replication and maintenance of DNA outside of Mitochondria. It is important in the diagnosis and treatment of cancer. Its presence in cells can be used to help determine the treatment options for patients with Leukemia. LIG3 can be found in all human tissues.
The LIG3 gene has been used in various applications in biology. The gene can be found in many branches and ancestors of the metazoan tree. However, it is rare in model organisms. Lig3 homologs can also be found in slime mold and fruit flies. Lig1 and Lig3 share 60% of their sequence identity. However, there is only 20% sequence identity between Lig3 and Lig4.
The 1960s saw the first isolation of LIG3 and it has since been widely used as a molecular genetic tool. It is found within all three major life forms. Lig3 is found in almost all cells in the human genome as well in most of the ancestral eukaryotes. However, it has been questioned as to whether it is located in mitochondria. The LIG3 genes are expressed in multiple cell types. Therefore, the exact function of this gene is not known.
The LIG3 gene encodes many DNA ligases, including nuclear LIG3 as well as mitochondrial LIG3. They are ATP-dependent. They seal breaks in duplex genetic material. They are an essential component of the excision process. However, LIG3 is also associated with mitochondrial DNA metabolic. It also contains a specialized Nterminal ZnF. This plays a critical role for sensing and intermolecularly ligating DNA molecules.
LIG3 expression in KD cells is 90% reduced. The LIG3 gene marker is not associated with mtDNA copy, but it is believed that 10% of its levels are sufficient for HeLa cells to maintain a normal mtDNA copy. The LIG3 marker is not cheap, despite its low price. So how much does the LIG3 markers cost?