DNA ligase 3 (LIG3)

Isoform 3 acts as heterodimer with DNA-repair protein XRCC1 in the nucleus and may fix defective DNA strand- break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents. Isoform 1 is targeted to mitochondria, where it acts as DNA ligase in mitochondrial base-excision DNA repair (PubMed:10207110, PubMed:24674627).