LYPLA1 Antibodies

AND LYPLA1 ELISA kits, LYPLA1 Proteins

Many biological assays use antibodies to detect LYPLA1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with LYPLA1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop LYPLA1 antibodies...

We validate the specificity of these antibodies to LYPLA1 by testing them on tissues known to express LYPLA1 positively and negatively. Browse below to find the LYPLA1 antibody that suites your experiment. We have 4 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Designing an IHC experiment for LYPLA1? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.

Open the LYPLA1 IHC Guide

LYPLA1 Infographic by Boster Bio

All LYPLA1 Products

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Applications

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Anti-LYPLA1 Antibody Picoband®

Western blot analysis of LYPLA1 using anti-LYPLA1 antibody (A16132-1)

IHC analysis of LYPLA1 using anti-LYPLA1 antibody (A07249-2)

Human, Mouse, Rat

ELISA, Flow Cytometry, IHC, WB

$370
Cat # A07249-2
100 µg/vial

Anti-Lysophospholipase 1 Rabbit Monoclonal Antibody

Western blot analysis of Lysophospholipase 1 expression in Human fetal liver lysate

Human, Mouse, Rat

Flow Cytometry, IF, ICC, WB

$370
Cat # M07249-1
100 μl/vial

Lysophospholipase 1 (LYPLA1) (NM_006330) Human Over-expression Lysate

Human

$628
Cat # LS010434
20 µg, 100 µg

Mouse LYPLA1 Recombinant Protein

SDS-PAGE

$250
Cat # PROTP97823
Starting from 20ug

LYPLA1 Overview

Facts about Acyl-protein thioesterase 1.

LYPLA1 3D structure. Source: alphafold

Acyl-protein thioesterase 1 (LYPLA1)

Hydrolyzes fatty acids from S-acylated cysteine residues in proteins like trimeric G alpha proteins or HRAS. Has depalmitoylating action toward KCNMA1.

Has low lysophospholipase activity. .

Gene Information

Human
Gene Name:	LYPLA1
Uniprot:	O75608
Entrez:	10434

Family

Belongs to:

AB hydrolase superfamily

Alternative Names

acyl-protein thioesterase-1; APT1; APT-1; EC 3.1.2; EC 3.1.2.-; hAPT1; LPL1acyl-protein thioesterase 1; LPL-I; Lysophospholipase 1; lysophospholipase ILYSOPLA; lysophospholipid-specific lysophospholipase; LysoPLA I

Molecular Weight

Mass (kDA):
24.67 kDA

Genomic Context


Human

Location:	8q11.23
Sequence:	8; NC_000008.11 (54046367..54102017, complement)

Subcellular Localizations

Cytoplasm.

Diseases

Bladder Neoplasm
Influenza
Malignant Neoplasm Of Prostate
Neoplasm Metastasis
Thrombus
Fowlpox
Stomatitis
Reticuloendothelial Hyperplasia
Physiological Stress
Vesicular Stomatitis
Carcinoma
Tumor Suppressor Gene Inactivation Process

Vascular System Injuries
Malignant Neoplasms
Prostatic Neoplasms
Nervousness
Poultry Diseases
Thrombosis
Decreased Immunologic Activity [pe]

Pathways

Localization
Protein Palmitoylation
Transport
Dna Hypermethylation
Dna Methylation
Platelet Activation
Prenylation
Platelet Aggregation
Dendritic Spine Morphogenesis
Methylation
Protein Deacylation
Gastric Motility

Lipid Modification
Translation
Regulation Of Appetite
Glycolysis
Lymphocyte Proliferation
Secretion

PTMs

Palmitoylation
Depalmitoylation
Acylation

Phosphorylation
Reduction
Cleavage

Methylation

Research Areas

Core ESC-Like Genes
Stem Cell Markers

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/LYPLA1

References

PMID: 11080636 by Devedjiev Y., et al. Crystal structure of the human acyl protein thioesterase I from a single X-ray data set to 1.5 A.

PMID: 20418879 by Dekker F.J., et al. Small-molecule inhibition of APT1 affects Ras localization and signaling.