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- Table of Contents
MANF Antibodies
AND MANF ELISA kits, MANF Proteins
Many biological assays use antibodies to detect MANF, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with MANF in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop MANF antibodies...
Designing a Western blot for MANF? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the MANF Western Blot GuideDesigning an IHC experiment for MANF? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the MANF IHC GuideMANF Infographic by Boster Bio
All MANF Products
Product
Figures
Specificity
Applications
Price
Human MANF ELISA Kit PicoKine®
4 Citations
Human
ELISA
$750
Cat # EK1845
96 wells/kit, with removable strips.
Cat # EK1845
96 wells/kit, with removable strips.
Human
ELISA, Flow Cytometry, Functional Assay, Kinetics
$486
Cat # M00807-2
100 μg
Cat # M00807-2
100 μg
Human, Mouse, Rat
Flow Cytometry, IHC, WB
$370
Cat # A03825-2
100 μg/vial
Cat # A03825-2
100 μg/vial
MANF Overview
Facts about Mesencephalic astrocyte-derived neurotrophic factor.
Mesencephalic astrocyte-derived neurotrophic factor (MANF)
Selectively promotes the survival of dopaminergic neurons of the ventral mid-brain (PubMed:12794311). Modulates GABAergic transmission to the dopaminergic neurons of the substantia nigra (By similarity).
Enhances spontaneous, as well as evoked, GABAergic inhibitory postsynaptic currents in dopaminergic neurons (By similarity). Inhibits cell proliferation and endoplasmic reticulum (ER) stress-induced cell death (PubMed:18561914, PubMed:22637475, PubMed:29497057).
Gene Information
| Human | |
|---|---|
| Gene Name: | MANF |
| Uniprot: | P55145 |
| Entrez: | 7873 |
Family
| Belongs to: |
|---|
| ARMET family |
Alternative Names
Arginine-Rich Protein; arginine-rich, mutated in early stage tumors; ARMET; ARP; MANF; mesencephalic astrocyte-derived neurotrophic factor; Protein ARMET
Molecular Weight
Mass (kDA):
20.7 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 3p21.2 |
| Sequence: | 3; NC_000003.12 (51385291..51389397) |
Subcellular Localizations
Secreted. Endoplasmic reticulum lumen. Sarcoplasmic reticulum lumen. Retained in the endoplasmic reticulum (ER), and sarcoplasmic reticulum (SR) under normal conditions (PubMed:22637475). Up-regulated and secreted by the ER/SR in response to ER stress and hypoxia (PubMed:22637475, PubMed:29497057).
Diseases
- Parkinson Disease
- Neoplasms
- Malignant Neoplasms
- Ischemia
- Endoplasmic Reticulum Stress
- Neurodegenerative Disorders
- Nervousness
- Brain Ischemia
- Physiological Stress
- Infarction
- Carcinoma
- Renal Cell Carcinoma
- Myocardial Ischemia
Pathways
- Localization
- Cell Death
- Transport
- Secretion
- Fertilization
- Nuclear Import
- Protein Folding
- Constitutive Secretory Pathway
- Brain Development
- Complement Activation
- Neurogenesis
- Nuclear Transport
- Cytokinesis
PTMs
- Glycosylation
Research Areas
- Cancer
- DNA Repair
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MANF
bosterbio.com/bosterbio-gene-info-cards/MANF
References
PMID: 8649854 by Shridhar V., et al. A gene from human chromosomal band 3p21.1 encodes a highly conserved arginine-rich protein and is mutated in renal cell carcinomas.
PMID: 12794311 by Petrova P., et al. MANF: a new mesencephalic, astrocyte-derived neurotrophic factor with selectivity for dopaminergic neurons.