MAP3K14 Antibodies

AND MAP3K14 ELISA kits, MAP3K14 Proteins

Many biological assays use antibodies to detect MAP3K14, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with MAP3K14 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop MAP3K14 antibodies...

We validate the specificity of these antibodies to MAP3K14 by testing them on tissues known to express MAP3K14 positively and negatively. Browse below to find the MAP3K14 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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MAP3K14 Infographic by Boster Bio

All MAP3K14 Products

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Anti-NIK MAP3K14 Antibody

Immunocytochemistry of NIK in Hek293 cells with NIK antibody at 10 μg/mL

Immunofluorescence of NIK in Hek293 cells with NIK antibody at 20 μg/mL

Human

ELISA, IF, ICC, WB

$481
Cat # A03822
0.1 mg

NFkB Inducing Kinase NIK (MAP3K14) (NM_003954) Human Over-expression Lysate

Human

$628
Cat # LS009020
20 µg, 100 µg

MAP3K14 Overview

Facts about Mitogen-activated protein kinase kinase kinase 14.

MAP3K14 3D structure. Source: alphafold

Mitogen-activated protein kinase kinase kinase 14 (MAP3K14)

Lymphotoxin beta-activated kinase which seems to be exclusively involved in the activation of NF-kappa-B and its transcriptional activity. Promotes proteolytic processing of NFKB2/P100, which contributes to activation of NF-kappa-B through the non- canonical pathway.

Could behave in a receptor-selective method. .

Gene Information

Human
Gene Name:	MAP3K14
Uniprot:	Q99558
Entrez:	9020

Family

Belongs to:

protein kinase superfamily

Alternative Names

EC 2.7.11.25; FTDCR1B; HS; HSNIK; HSNIKserine/threonine protein-kinase; MAP3K14; mitogen-activated protein kinase kinase kinase 14; NIK; NIKNF-kappa-beta-inducing kinase; Serine/threonine-protein kinase NIK

Molecular Weight

Mass (kDA):
104.042 kDA

Genomic Context


Human

Location:	17q21.31
Sequence:	17; NC_000017.11 (45263119..45317048, complement)

Tissue Specificity

Weakly expressed in testis, small intestine, spleen, thymus, peripheral blood leukocytes, prostate, ovary and colon.

Subcellular Localizations

Cytoplasm.

Diseases

Malignant Neoplasms
Lymphoma
Classical Hodgkin's Lymphoma
Immunologic Deficiency Syndromes
Neoplasms
Rheumatoid Arthritis
Arthritis
Inflammation
Hodgkin Disease
Cholangiocarcinoma
Neoplasm Metastasis
Chikungunya Virus Infection
Melanoma

Glioma
Lung Diseases
Sarcoma
Metastatic Malignant Neoplasm To The Pancreas
Lung Diseases, Obstructive
Fibrosarcoma
Radiation Induced Dna Damage

Interacting Proteins

ALPL
CDC37
CHUK
HSP90AA1
HSP90AB1

IKBKB
KPNB1
TRAF2
TRAF3
TRAF6

Pathways

Pathogenesis
Cell Migration
Cell Proliferation
Aging
Dna Methylation
Immune Response
Regulation Of Gene Expression
Methylation
Drug Resistance
Reverse Transcription

Organ Development
Cell Death
Interphase
Histone Methylation
Rna Interference

PTMs

Phosphorylation

Methylation

Research Areas

Apoptosis
Cancer
Protein Kinase
Signal Transduction

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MAP3K14

References

PMID: 9020361 by Malinin N.L., et al. MAP3K-related kinase involved in NF-kappaB induction by TNF, CD95 and IL-1.

PMID: 12874243 by Jensen L.E., et al. Pellino3, a novel member of the Pellino protein family, promotes activation of c-Jun and Elk-1 and may act as a scaffolding protein.