DNA helicase MCM8 (Mcm8)

Part of the MCM8-MCM9 complex, a complex involved in homologous recombination repair following DNA interstrand cross-links and plays an integral role during gametogenesis. The MCM8- MCM9 complex probably functions as a hexameric helicase downstream of the Fanconi anemia proteins BRCA2 and RAD51 and is needed to process aberrant forks into homologous recombination substrates and to orchestrate homologous recombination with resection, fork stabilization and fork restart.

May also play a non-essential for DNA replication: may be involved in the activation of the prereplicative complex (pre-RC) during G(1) phase by recruitment CDC6 to the origin recognition complex (ORC). Binds chromatin throughout the cell cycle.