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- Table of Contents
Facts about Mediator of RNA polymerase II transcription subunit 7.
Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. .
Human | |
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Gene Name: | MED7 |
Uniprot: | O43513 |
Entrez: | 9443 |
Belongs to: |
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Mediator complex subunit 7 family |
Activator-recruited cofactor 34 kDa component; Cofactor required for Sp1 transcriptional activation subunit 9; cofactor required for Sp1 transcriptional activation, subunit 9 (33kD); cofactor required for Sp1 transcriptional activation, subunit 9, 33kDa; CRSP33CRSP complex subunit 9; CRSP9hMED7; mediator complex subunit 7ARC34; mediator of RNA polymerase II transcription subunit 7; MGC12284; RNA polymerase transcriptional regulation mediator subunit 7 homolog; Transcriptional coactivator CRSP33
Mass (kDA):
27.245 kDA
Human | |
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Location: | 5q33.3 |
Sequence: | 5; NC_000005.10 (157137424..157142865, complement) |
Nucleus.
PMID: 9671713 by Jiang Y.W., et al. Mammalian mediator of transcriptional regulation and its possible role as an end-point of signal transduction pathways.
PMID: 9989412 by Ryu S., et al. The transcriptional cofactor complex CRSP is required for activity of the enhancer-binding protein Sp1.