Meprin A subunit beta Antibodies

AND MEP1B ELISA kits, Meprin A subunit beta Proteins

Many biological assays use antibodies to detect Meprin A subunit beta, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Meprin A subunit beta in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Meprin A subunit beta antibodies...

We validate the specificity of these antibodies to Meprin A subunit beta by testing them on tissues known to express MEP1B positively and negatively. Browse below to find the MEP1B antibody that suites your experiment. We have 4 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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MEP1B Infographic by Boster Bio

All MEP1B Products

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Anti-Meprin A subunit beta MEP1B Antibody

Human, Mouse, Rat

ELISA, WB

$380
Cat # A06392
100ul

Mouse Meprin beta Subunit/MEP1B Recombinant Protein

SDS-PAGE

$350
Cat # PROTQ61847
Starting from 10ug

Meprin beta (MEP1B) (NM_005925) Human Over-expression Lysate

Human

$960
Cat # LS004225
20 µg, 100 µg

Anti-MEP1B Antibody Picoband®

Western blot analysis of MEP1B using anti-MEP1B antibody (A06392-1)

IHC analysis of MEP1B using anti-MEP1B antibody (A06392-1)

Human, Mouse, Rat

ELISA, IF, IHC, WB

$370
Cat # A06392-1
100 µg/vial

MEP1B Overview

Facts about Meprin A subunit beta.

MEP1B 3D structure. Source: alphafold

Meprin A subunit beta (MEP1B)

Membrane metallopeptidase that sheds many membrane-bound proteins. Exhibits a strong preference for acidic amino acids at the P1' position.

Known substrates include: FGF19, VGFA, IL1B, IL18, procollagen I and III, E-cadherin, KLK7, gastrin, ADAM10, tenascin-C. The presence of numerous pro-inflammatory cytokine one of substrates implicate MEP1B in inflammation.

Gene Information

Human
Gene Name:	MEP1B
Uniprot:	Q16820
Entrez:	4225

Family

Belongs to:

No superfamily

Alternative Names

EC 3.4.24.63; endopeptidase-2; MEP1B; meprin A subunit beta; meprin A, beta; Meprin B; Meprin beta Subunit; N-benzoyl-L-tyrosyl-p-amino-benzoic acid hydrolase beta subunit; N-benzoyl-L-tyrosyl-P-amino-benzoic acid hydrolase subunit beta; PABA peptide hydrolase; PPH beta

Molecular Weight

Mass (kDA):
79.571 kDA

Genomic Context


Human

Location:	18q12.1
Sequence:	18; NC_000018.10 (32190039..32222607)

Tissue Specificity

The major site of expression is the brush border membrane of small intestinal and kidney epithelial cells.

Subcellular Localizations

Cell membrane; Single-pass type I membrane protein. Secreted. Homodimers are essentially membrane bound but may also be shed from the surface by ADAM-10 and ADAM-17.

Diseases

Endometrial Polyp
Tissue Adhesions
Kidney Diseases
Cell Transformation, Neoplastic
Diabetic Nephropathy
Autosomal Recessive Polycystic Kidney Disease
Dentin Dysplasia
Carcinoma
Dysplasia
Diabetes Mellitus, Non-insulin-dependent
Endometriosis, Site Unspecified
Tumor Angiogenesis

Polycystic Kidney Diseases
Malignant Neoplasms
Neoplasms
Dentinogenesis Imperfecta
Cattle Diseases
Dysequilibrium Syndrome

Interacting Proteins

MMP9
TSPAN8

Pathways

Cell Adhesion
Transport
Immune Response
Odontogenesis
Ovulation
Localization
Dentinogenesis
Cell Cycle
Cell Death
Cell Growth

Angiogenesis
Invasive Growth
Estrus
Regulation Of Angiogenesis

PTMs

Cleavage

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MEP1B

References

PMID: 9288916 by Eldering J.A., et al. Polarised expression of human intestinal N-benzoyl-L-tyrosyl-p- aminobenzoic acid hydrolase (human meprin) alpha and beta subunits in Madin-Darby canine kidney cells.

PMID: 8262185 by Dumermuth E., et al. Cloning of the PABA peptide hydrolase alpha subunit (PPH alpha) from human small intestine and its expression in COS-1 cells.