Meprin A subunit beta (MEP1B)

Membrane metallopeptidase that sheds many membrane-bound proteins. Exhibits a strong preference for acidic amino acids at the P1' position.

Known substrates include: FGF19, VGFA, IL1B, IL18, procollagen I and III, E-cadherin, KLK7, gastrin, ADAM10, tenascin-C. The presence of numerous pro-inflammatory cytokine one of substrates implicate MEP1B in inflammation.