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- Table of Contents
Facts about Sodium-dependent lysophosphatidylcholine symporter 1.
Transport of LPC is essential because it constitutes the significant mechanism by which docosahexaenoic acid (DHA), an omega-3 fatty acid that is essential for normal brain growth and cognitive function, enters the brain. Transports LPC carrying long-chain fatty acids such LPC oleate and LPC palmitate with a minimum acyl chain length of 14 carbons.
Mouse | |
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Gene Name: | Mfsd2a |
Uniprot: | Q9DA75 |
Entrez: | 76574 |
Belongs to: |
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major facilitator superfamily |
FLJ14490; FLJ35904; major facilitator superfamily domain containing 2; major facilitator superfamily domain containing 2A; major facilitator superfamily domain-containing protein 2A; MFSD2
Mass (kDA):
58.984 kDA
Mouse | |
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Location: | 4|4 D2.2 |
Sequence: | 4; |
Widely expressed. Exhibits an oscillatory pattern of expression in brown adipose tissue and liver consistent with a circadian rhythm. Enriched in brain micro-vessels, where it is specifically present in endothelium constituting the blood- brain barrier (at protein level) (PubMed:24828044, PubMed:24828040).
PMID: 18694395 by Angers M., et al. Mfsd2a encodes a novel major facilitator superfamily domain- containing protein highly induced in brown adipose tissue during fasting and adaptive thermogenesis.
PMID: 23209793 by Berger J.H., et al. Major facilitator superfamily domain-containing protein 2a (MFSD2A) has roles in body growth, motor function, and lipid metabolism.