MICAL2 Antibodies

AND MICAL2 ELISA kits, MICAL2 Proteins

Many biological assays use antibodies to detect MICAL2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with MICAL2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop MICAL2 antibodies...

We validate the specificity of these antibodies to MICAL2 by testing them on tissues known to express MICAL2 positively and negatively. Browse below to find the MICAL2 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Designing an IHC experiment for MICAL2? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.

Open the MICAL2 IHC Guide

MICAL2 Infographic by Boster Bio

All MICAL2 Products

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Anti-MICAL2 Antibody

1 Citations

IHC analysis of MICAL2 using anti-MICAL2 antibody (A08683-1)

Human, Mouse, Rat

ELISA, IF, IHC, ICC, WB

$370
Cat # A08683-1
100 μl/vial

MICAL2 (NM_014632) Human Over-expression Lysate

Human

$628
Cat # LS009645
20 µg, 100 µg

MICAL2 Overview

Facts about [F-actin]-monooxygenase MICAL2.

MICAL2 3D structure. Source: alphafold

[F-actin]-monooxygenase MICAL2 (MICAL2)

Nuclear monooxygenase that boosts depolymerization of F-actin by mediating oxidation of certain methionine residues on actin to form methionine-sulfoxide, leading to actin filament disassembly and preventing repolymerization (PubMed:24440334). In the absence of actin, in addition, it acts as a NADPH oxidase producing H(2)O(2) (By similarity).

Acts as a key regulator of the SRF signaling pathway elicited by nerve growth factor and serum: mediates oxidation and subsequent depolymerization of nuclear actin, resulting in increase MKL1/MRTF-A existence in the nucleus and encourage SRF:MKL1/MRTF-A-dependent gene transcription. Doesn't activate SRF:MKL1/MRTF-A through RhoA (PubMed:24440334).

Gene Information

Human
Gene Name:	MICAL2
Uniprot:	O94851
Entrez:	9645

Family

Belongs to:

Mical family

Alternative Names

DKFZp686H03148; DKFZp686H2469; flavoprotein oxidoreductase MICAL2; KIAA0750MICAL2PV2; MICAL2PV1; microtubule associated monoxygenase, calponin and LIM domain containing 2; protein MICAL-2

Molecular Weight

Mass (kDA):
126.689 kDA

Genomic Context


Human

Location:	11p15.3
Sequence:	11; NC_000011.10 (12110576..12263790)

Subcellular Localizations

Nucleus.

Diseases

Malignant Neoplasms
Neoplasms
Bladder Neoplasm
Malignant Neoplasm Of Prostate
Cell Transformation, Neoplastic
Intraepithelial Neoplasia
Oncogene Deregulation
Tumor Progression
Prostatic Intraepithelial Neoplasias
Muscular Dystrophy, Duchenne
Tissue Adhesions

Malignant Neoplasm Of Urinary Bladder
Carcinoma
Muscle Necrosis
Carcinoma In Situ
Prostatic Neoplasms
Muscular Dystrophy, Animal

Pathways

Transport
Cell Adhesion
Intracellular Transport
Cell Differentiation
Pathogenesis

PTMs

Phosphoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MICAL2

References

PMID: 16675569 by Ashida S., et al. Expression of novel molecules, MICAL2-PV (MICAL2 prostate cancer variants), increases with high Gleason score and prostate cancer progression.

PMID: 12110185 by Terman J.R., et al. MICALs, a family of conserved flavoprotein oxidoreductases, function in plexin-mediated axonal repulsion.