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Melanophilin Antibodies
AND MLPH ELISA kits, Melanophilin Proteins
Many biological assays use antibodies to detect Melanophilin, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Melanophilin in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Melanophilin antibodies...
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MLPH Infographic by Boster Bio
All MLPH Products
Product
Figures
Specificity
Applications
Price
Human
IHC, WB
$523
Cat # M06081
100 µl
Cat # M06081
100 µl
MLPH Overview
Facts about Melanophilin.
Melanophilin (MLPH)
Rab effector protein involved in melanosome transport. Serves as link between melanosome-bound RAB27A and the motor protein MYO5A.
.
Gene Information
| Human | |
|---|---|
| Gene Name: | MLPH |
| Uniprot: | Q9BV36 |
| Entrez: | 79083 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
exophilin-3; l(1)-3Rk; l1Rk3; ln; melanophilin; MGC2771; MGC59733; SLAC2A; Slac-2a; SLAC2-A; Slp homolog lacking C2 domains a; Synaptotagmin-like protein 2a
Molecular Weight
Mass (kDA):
65.949 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 2q37.3 |
| Sequence: | 2; NC_000002.12 (237486410..237555322) |
Subcellular Localizations
Cytoplasm.
Diseases
- Hypopigmentation-immunodeficiency Disease
- Immunologic Deficiency Syndromes
- Melanoma
- Piebaldism
- Albinism
- Hypopigmentation Disorder
- Pigmentation Disorders
- Malignant Neoplasms
- Metabolic Bone Disorder
- Griscelli Syndrome, Type 2
- Dysplasia
- Neoplasms
- Inflammation
Interacting Proteins
- RAB27A
- RAB27B
Pathways
- Transport
- Melanosome Transport
- Pigmentation
- Localization
- Exocytosis
- Vesicle Transport
- Secretion
- Intracellular Transport
- Proteolysis
- Cell Differentiation
- Pathogenesis
- Cell Adhesion
- Secretory Pathway
PTMs
- Phosphorylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MLPH
bosterbio.com/bosterbio-gene-info-cards/MLPH
References
PMID: 12062444 by Nagashima K., et al. Melanophilin directly links Rab27a and myosin Va through its distinct coiled-coil regions.
PMID: 12897212 by Menasche G., et al. Griscelli syndrome restricted to hypopigmentation results from a melanophilin defect (GS3) or a MYO5A F-exon deletion (GS1).