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- Table of Contents
MSH2 Antibodies
AND MSH2 ELISA kits, MSH2 Proteins
Many biological assays use antibodies to detect MSH2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with MSH2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop MSH2 antibodies...
Designing a Western blot for MSH2? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the MSH2 Western Blot GuideMSH2 Infographic by Boster Bio
All MSH2 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # PB9284
100 μg/vial
Cat # PB9284
100 μg/vial
Human
IF, IHC, ICC, WB
$370
Cat # M00140-5
100 μg/vial
Cat # M00140-5
100 μg/vial
MSH2 Overview
Facts about DNA mismatch repair protein Msh2.
DNA mismatch repair protein Msh2 (MSH2)
Component of the post-replicative DNA mismatch repair system (MMR). Forms two unique heterodimers: MutS alpha (MSH2- MSH6 heterodimer) and MutS beta (MSH2-MSH3 heterodimer) which binds to DNA mismatches thereby initiating DNA repair.
When bound, heterodimers bend the DNA helix and protects approximately 20 base pairs. MutS alpha recognizes single base mismatches and dinucleotide insertion-deletion loops (IDL) from the DNA.
Gene Information
| Human | |
|---|---|
| Gene Name: | MSH2 |
| Uniprot: | P43246 |
| Entrez: | 4436 |
Family
| Belongs to: |
|---|
| DNA mismatch repair MutS family |
Alternative Names
COCA1; DNA mismatch repair protein Msh2; FCC1; hMSH2; HNPCC; HNPCC1; HNPCC1mutS (E. coli) homolog 2 (colon cancer, nonpolyposis type 1); LCFS2; MSH2; mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli); MutS protein homolog 2
Molecular Weight
Mass (kDA):
104.743 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 2p21-p16.3 |
| Sequence: | 2; NC_000002.12 (47403067..47634501) |
Tissue Specificity
Ubiquitously expressed.
Subcellular Localizations
Nucleus. Chromosome.
Diseases
- Malignant Neoplasms
- Neoplasms
- Colorectal Cancer
- Hereditary Nonpolyposis Colorectal Cancer
- Microsatellite Instability
- Carcinoma
- Colorectal Neoplasms
- Malignant Tumor Of Colon
- Endometrial Polyp
- Adenocarcinoma
- Endometrial Carcinoma
- Carcinogenesis
Interacting Proteins
- E2F3
- HMGB1
- MSH3
- MSH6
- SLX4
Pathways
- Mismatch Repair
- Dna Repair
- Methylation
- Dna Replication
- Pathogenesis
- Cell Cycle
- Cell Death
- Gene Conversion
- Localization
- Drug Resistance
- Meiosis
- Dna Methylation
- Cell Proliferation
PTMs
- Methylation
- Phosphorylation
- Deamination
- Cleavage
- Demethylation
- Biotinylation
Research Areas
- Breast Cancer
- Cancer
- Core ESC-Like Genes
- DNA Repair
- Mismatch Repair
- Stem Cell Markers
- Tumor Suppressors
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MSH2
bosterbio.com/bosterbio-gene-info-cards/MSH2
References
PMID: 8252616 by Fishel R., et al. The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer.
PMID: 8261515 by Leach F.S., et al. Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer.
1 Publications of Boster MSH2 Antibodies & ELISA Kits
- PubMed ID: 23485110, Zhang Yx, Yue Z, Wang Py, Li Yj, Xin Jx, Pang M, Zheng Qy, Xie Sy. Biomed Pharma...
*More publications can be found for each product on its corresponding product page