MTHFD1 Antibodies

AND MTHFD1 ELISA kits, MTHFD1 Proteins

Many biological assays use antibodies to detect MTHFD1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with MTHFD1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop MTHFD1 antibodies...

We validate the specificity of these antibodies to MTHFD1 by testing them on tissues known to express MTHFD1 positively and negatively. Browse below to find the MTHFD1 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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MTHFD1 Infographic by Boster Bio

All MTHFD1 Products

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Product

Figures

Specificity

Applications

Price

Anti-MTHFD1 Antibody

Western blot analysis of extracts of various cell lines, using MTHFD1 antibody at 1:1000 dilution

Human, Mouse, Rat

IF, ICC, WB

$405
Cat # A02025
100ul

Anti-MTHFD1 Antibody Picoband®

Western blot analysis of MTHFD1 using anti-MTHFD1 antibody (A02025-1)

IHC analysis of MTHFD1 using anti-MTHFD1 antibody (A02025-1)

Human, Mouse, Rat

ELISA, Flow Cytometry, IF, IHC, ICC, WB

$370
Cat # A02025-1
100 μg/vial

MTHFD1 (NM_005956) Human Over-expression Lysate

Human

$628
Cat # LS004522
20 µg, 100 µg

MTHFD1 Overview

Facts about C-1-tetrahydrofolate synthase, cytoplasmic.

MTHFD1 3D structure. Source: alphafold

C-1-tetrahydrofolate synthase, cytoplasmic (MTHFD1)

Gene Information

Human
Gene Name:	MTHFD1
Uniprot:	P11586
Entrez:	4522

Family

Belongs to:

No superfamily

Alternative Names

C1-THF synthase; EC 6.3.4.3; methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase5,10-methylenetetrahydrofolate dehydrogenase, 5,10-methylenetetrahydrofolatecyclohydrolase, 10-formyltetrahydrofolate synthetase; methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1; MTHFCC-1-tetrahydrofolate synthase, cytoplasmic; MTHFDcytoplasmic C-1-tetrahydrofolate synthase

Molecular Weight

Mass (kDA):
101.559 kDA

Genomic Context


Human

Location:	14q23.3
Sequence:	14; NC_000014.9 (64388353..64460025)

Tissue Specificity

Ubiquitous.

Subcellular Localizations

Cytoplasm.

Diseases

5,10-methylenetetrahydrofolate Reductase Deficiency
Malignant Neoplasms
Neoplasms
Leukemia
Hyperhomocysteinemia
L1 Acute Lymphoblastic Leukemia
Acute Lymphocytic Leukemia
Carcinoma
Carcinogenesis
Congenital Abnormality
Cleft Palate
Head And Neck Neoplasms
Cleft Lip

Cholangiocarcinoma
Dysequilibrium Syndrome
Malignant Head And Neck Neoplasm
Congenital Heart Defects
Folic Acid Deficiency
Malignant Neoplasm Of Breast
Malignant Neck Neoplasm

Pathways

Methylation
Dna Methylation
Neural Tube Closure
Tube Closure
Transport
Pathogenesis
Transsulfuration
Transposition
Dna Hypermethylation
Brain Development

Oxidative Phosphorylation
Embryo Development
Drug Resistance
Mrna Splicing
Vacuolar Acidification

PTMs

Methylation

Reduction

Research Areas

Stem Cell Markers

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MTHFD1

References

PMID: 3053686 by Hum D.W., et al. Primary structure of a human trifunctional enzyme. Isolation of a cDNA encoding methylenetetrahydrofolate dehydrogenase- methenyltetrahydrofolate cyclohydrolase-formyltetrahydrofolate synthetase.

PMID: 9519408 by Allaire M., et al. The 3-D structure of a folate-dependent dehydrogenase/cyclohydrolase bifunctional enzyme at 1.5-A resolution.