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MTHFR Antibodies
AND MTHFR ELISA kits, MTHFR Proteins
Many biological assays use antibodies to detect MTHFR, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with MTHFR in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop MTHFR antibodies...
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MTHFR Overview
Facts about Methylenetetrahydrofolate reductase.
Methylenetetrahydrofolate reductase (MTHFR)
Catalyzes the conversion of 5,10- methylenetetrahydrofolate to 5-methyltetrahydrofolate, a co- substrate for homocysteine remethylation to methionine. .
Gene Information
| Human | |
|---|---|
| Gene Name: | MTHFR |
| Uniprot: | P42898 |
| Entrez: | 4524 |
Family
| Belongs to: |
|---|
| methylenetetrahydrofolate reductase family |
Alternative Names
EC 1.5.1.20; methylenetetrahydrofolate reductase (NAD(P)H)5,10-methylenetetrahydrofolate reductase (NADPH); methylenetetrahydrofolate reductase
Molecular Weight
Mass (kDA):
74.597 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 1p36.22 |
| Sequence: | 1; NC_000001.11 (11785723..11806103, complement) |
Diseases
- 5,10-methylenetetrahydrofolate Reductase Deficiency
- Hyperhomocysteinemia
- Malignant Neoplasms
- Cholangiocarcinoma
- Thrombosis
- Thrombophilia
- Cardiovascular Diseases
- Cerebrovascular Accident
- Venous Thrombosis
- Neoplasms
- Vascular Diseases
- Hypertensive Disease
- Coronary Artery Disease
Pathways
- Methylation
- Dna Methylation
- Pathogenesis
- Coagulation
- Dna Repair
- Dna Hypomethylation
- Transport
- Aging
- Hemostasis
- Transsulfuration
- Blood Coagulation
- Glomerular Filtration
- Excretion
PTMs
- Methylation
- Reduction
- Phosphorylation
- Demethylation
- Cleavage
- Formylation
- Acetylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MTHFR
bosterbio.com/bosterbio-gene-info-cards/MTHFR
References
PMID: 9680386 by Goyette P., et al. Gene structure of human and mouse methylenetetrahydrofolate reductase (MTHFR).
PMID: 7920641 by Goyette P., et al. Human methylenetetrahydrofolate reductase: isolation of cDNA, mapping and mutation identification.