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MTMR12 Antibodies
AND MTMR12 ELISA kits, MTMR12 Proteins
Many biological assays use antibodies to detect MTMR12, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with MTMR12 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop MTMR12 antibodies...
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MTMR12 Overview
Facts about Myotubularin-related protein 12.
Myotubularin-related protein 12 (MTMR12)
Catalytically inactive phosphatase that plays a role as an adapter for the phosphatase myotubularin to modulate myotubularin intracellular location. .
Gene Information
| Human | |
|---|---|
| Gene Name: | MTMR12 |
| Uniprot: | Q9C0I1 |
| Entrez: | 54545 |
Family
| Belongs to: |
|---|
| protein-tyrosine phosphatase family |
Alternative Names
3-PAP3PAP; 3-phosphatase adapter subunit; KIAA1682FLJ20476; myotubularin related protein 12; myotubularin-related protein 12,3-phosphatase adapter protein; Phosphatidylinositol-3 phosphate 3-phosphatase adapter subunit; phosphatidylinositol-3 phosphate 3-phosphatase adaptor subunit; phosphatidylinositol-3-phosphate associated protein; PIP3AP
Molecular Weight
Mass (kDA):
86.148 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 5p13.3 |
| Sequence: | 5; NC_000005.10 (32227007..32312939, complement) |
Tissue Specificity
Ubiquitous with prominent expression in brain, heart, kidney, placenta, and lung.
Subcellular Localizations
Cytoplasm. Sarcoplasmic reticulum. Cytoplasm, myofibril, sarcomere. Localizes to punctate vesicles when associated with MTM1 (PubMed:12847286). Localizes to triads, a structure formed by a T tubule and two sarcoplasmic reticulum terminal cisterna (By similarity). In skeletal muscles, co-localizes with MTM1 in the sarcomere (By similarity). Partially localizes to the sarcoplasmic reticulum in skeletal muscles (By similarity).
Diseases
- Learning Disorders
- Neoplasm Metastasis
- Cri-du-chat Syndrome
- Schizophrenia
- Neoplasm Invasiveness
- Congenital Anomaly Of Face
- Mental Disorders
- Myopathy
Interacting Proteins
- MTM1
Pathways
- Cell Migration
PTMs
Research Areas
- Protein Phosphatase
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MTMR12
bosterbio.com/bosterbio-gene-info-cards/MTMR12
References
PMID: 11504939 by Nandurkar H.H., et al. Characterization of an adapter subunit to a phosphatidylinositol (3)P 3-phosphatase: identification of a myotubularin-related protein lacking catalytic activity.
PMID: 12847286 by Nandurkar H.H., et al. Identification of myotubularin as the lipid phosphatase catalytic subunit associated with the 3-phosphatase adapter protein, 3-PAP.