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- Table of Contents
MTUS1 Antibodies
AND MTUS1 ELISA kits, MTUS1 Proteins
Many biological assays use antibodies to detect MTUS1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with MTUS1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop MTUS1 antibodies...
Designing a Western blot for MTUS1? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the MTUS1 Western Blot GuideMTUS1 Infographic by Boster Bio
All MTUS1 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, Flow Cytometry, WB
$370
Cat # A04050-2
100 μg/vial
Cat # A04050-2
100 μg/vial
MTUS1 Overview
Facts about Microtubule-associated tumor suppressor 1.
Microtubule-associated tumor suppressor 1 (MTUS1)
Cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. May be necessary for AGTR2 cell surface expression.
Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation. Isoform 1 inhibits breast cancer cell regeneration, delays the progression of mitosis by prolonging metaphase and reduces tumor growth.
Gene Information
| Human | |
|---|---|
| Gene Name: | MTUS1 |
| Uniprot: | Q9ULD2 |
| Entrez: | 57509 |
Family
| Belongs to: |
|---|
| MTUS1 family |
Alternative Names
Angiotensin-II type 2 receptor-interacting protein; AT2 receptor-binding protein; AT2R binding protein; ATBPATIP1; ATIP; DKFZp586D1519; erythroid differentiation-related; FLJ14295; GK1; KIAA1288DKFZp686F20243; microtubule associated tumor suppressor 1; microtubule-associated tumor suppressor 1; Mitochondrial tumor suppressor 1; mitochondrial tumor suppressor gene 1; MP44; MTSG1AT2 receptor-interacting protein; transcription factor MTSG1
Molecular Weight
Mass (kDA):
141.397 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 8p22 |
| Sequence: | 8; NC_000008.11 (17643794..17801579, complement) |
Tissue Specificity
Ubiquitously expressed (at protein level). Highly expressed in brain. Down-regulated in ovarian carcinoma, pancreas carcinoma, colon carcinoma and head and neck squamous cell carcinoma (HNSCC). Isoform 1 is the major isoform in most peripheral tissues. Isoform 2 is abundant in most peripheral tissues. Isoform 3 is the major isoform in brain, female reproductive tissues, thyroid and heart. Within brain it is highly expressed in corpus callosum and pons. Isoform 6 is brain- specific, it is the major isoform in cerebellum and fetal brain.
Subcellular Localizations
Mitochondrion. Golgi apparatus. Cell membrane. Nucleus. In neurons, translocates into the nucleus after treatment with angiotensin-II.; [Isoform 1]: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Localizes with the mitotic spindle during mitosis and with the intercellular bridge during cytokinesis.
Diseases
- Neoplasms
- Malignant Neoplasms
- Carcinoma
- Carcinogenesis
- Malignant Neoplasm Of Breast
- Mammary Neoplasms
- Colonic Neoplasms
- Hyperplasia
- Malignant Tumor Of Colon
- Malignant Paraganglionic Neoplasm
- Cardiovascular Diseases
- Colorectal Cancer
Pathways
- Cell Proliferation
- Cell Growth
- Methylation
- Cell Division
- Negative Regulation Of Protein Kinase Activity
- Regulation Of Protein Kinase Activity
- Mitosis
- Dedifferentiation
PTMs
Research Areas
- Breast Cancer
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MTUS1
bosterbio.com/bosterbio-gene-info-cards/MTUS1
References
PMID: 10697957 by Kinjo T., et al. Molecular cloning and characterization of two novel genes on chromosome 8p21.3.
PMID: 12692079 by Seibold S., et al. Identification of a new tumor suppressor gene located at chromosome 8p21.3-22.