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- Table of Contents
Mastl Antibodies
AND Mastl ELISA kits, Mastl Proteins
Many biological assays use antibodies to detect Mastl, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Mastl in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Mastl antibodies...
Designing a Western blot for Mastl? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the MASTL Western Blot GuideMastl Infographic by Boster Bio
All Mastl Products
Product
Figures
Specificity
Applications
Price
Human
ELISA, Flow Cytometry, IF, ICC, WB
$370
Cat # A04567-3
100 µg/vial
Cat # A04567-3
100 µg/vial
Human, Mouse
ELISA
$480
Cat # EKC1899
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1899
1 kit, containing one 96-well plate and all necessary reagents
Mastl Overview
Facts about Serine/threonine-protein kinase greatwall.
Serine/threonine-protein kinase greatwall (Mastl)
Serine/threonine kinase that plays an integral role in M phase by acting as a regulator of mitosis entry and maintenance. Acts by promoting the inactivation of protein phosphatase 2A (PP2A) during M phase: does not directly inhibit PP2A but functions by mediating phosphorylation and subsequent activation of ARPP19 and ENSA in'Ser-62' and'Ser-67', respectively.
ARPP19 and ENSA are phosphatase inhibitors that specifically inhibit the PPP2R2D (PR55-delta) subunit of PP2A. Inactivation of PP2A during M phase is vital to maintain cyclin-B1-CDK1 activity high.
Gene Information
| Mouse | |
|---|---|
| Gene Name: | Mastl |
| Uniprot: | Q8C0P0 |
| Entrez: | 67121 |
Family
| Belongs to: |
|---|
| protein kinase superfamily |
Alternative Names
FLJ14813EC 2.7.11.1; Greatwall; GW; GWL; hGWL; MASTL; MAST-L; microtubule associated serine/threonine kinase-like; Microtubule-associated serine/threonine-protein kinase-like; RP11-85G18.2; THC2; THC2greatwall protein kinase
Molecular Weight
Mass (kDA):
95.975 kDA
Genomic Context
| Mouse | |
|---|---|
| Location: | 2|2 A3 |
| Sequence: | 2; |
Diseases
- Malignant Neoplasms
- Neoplasms
- Primary Myelofibrosis
- Blood Platelet Disorders
- Neoplasms, Experimental
- Genomic Instability
- Polyploidy
- Tissue Adhesions
- Haploinsufficiency
- Congenital Thrombocytopenia
Pathways
- Mitosis
- Cell Cycle
- Anaphase
- Cell Division
- Asymmetric Cell Division
- Cell Death
- Interphase
- Exit From Mitosis
- Chromosome Condensation
PTMs
Research Areas
- Protein Kinase
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Mastl
bosterbio.com/bosterbio-gene-info-cards/Mastl
References
PMID: 21156286 by Manchado E., et al. Targeting mitotic exit leads to tumor regression in vivo: Modulation by Cdk1, Mastl, and the PP2A/B55alpha,delta phosphatase.