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DNA helicase MCM8 Antibodies
AND Mcm8 ELISA kits, DNA helicase MCM8 Proteins
Many biological assays use antibodies to detect DNA helicase MCM8, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with DNA helicase MCM8 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop DNA helicase MCM8 antibodies...
Designing a Western blot for DNA helicase MCM8? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the MCM8 Western Blot GuideMcm8 Infographic by Boster Bio
All Mcm8 Products
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Mcm8 Overview
Facts about DNA helicase MCM8.
DNA helicase MCM8 (Mcm8)
Part of the MCM8-MCM9 complex, a complex involved in homologous recombination repair following DNA interstrand cross-links and plays an integral role during gametogenesis. The MCM8- MCM9 complex probably functions as a hexameric helicase downstream of the Fanconi anemia proteins BRCA2 and RAD51 and is needed to process aberrant forks into homologous recombination substrates and to orchestrate homologous recombination with resection, fork stabilization and fork restart.
May also play a non-essential for DNA replication: may be involved in the activation of the prereplicative complex (pre-RC) during G(1) phase by recruitment CDC6 to the origin recognition complex (ORC). Binds chromatin throughout the cell cycle.
Gene Information
| Mouse | |
|---|---|
| Gene Name: | Mcm8 |
| Uniprot: | Q9CWV1 |
| Entrez: | 66634 |
Family
| Belongs to: |
|---|
| MCM family |
Alternative Names
C20orf154; chromosome 20 open reading frame 154; dJ967N21.5; DNA replication licensing factor MCM8; MCM8 minichromosome maintenance deficient 8; MGC119522; MGC119523; MGC12866; MGC4816; Minichromosome maintenance 8; minichromosome maintenance complex component 8; REC homolog; REC
Molecular Weight
Mass (kDA):
92.371 kDA
Genomic Context
| Mouse | |
|---|---|
| Location: | 2|2 F2 |
| Sequence: | 2; |
Diseases
- Premature Menopause
- Neoplasms
- Neuroblastoma
- Adenocarcinoma
- Fanconi Anemia
- Anemia
- Malignant Neoplasm Of Breast
- Colonic Neoplasms
- Genomic Instability
- Choriocarcinoma
- Infertility
Pathways
- Dna Replication
- Menopause
- S Phase
- Dna Replication Initiation
- Cell Cycle
- Menarche
- Cell Proliferation
- Meiotic Prophase I
- Dna Repair
- Gene Conversion
PTMs
Research Areas
- DNA Repair
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Mcm8
bosterbio.com/bosterbio-gene-info-cards/Mcm8
References
PMID: 22771120 by Lutzmann M., et al. MCM8- and MCM9-deficient mice reveal gametogenesis defects and genome instability due to impaired homologous recombination.