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Meprin A subunit beta Antibodies
AND MEP1B ELISA kits, Meprin A subunit beta Proteins
Many biological assays use antibodies to detect Meprin A subunit beta, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Meprin A subunit beta in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Meprin A subunit beta antibodies...
Designing an IHC experiment for Meprin A subunit beta? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the MEP1B IHC GuideMEP1B Infographic by Boster Bio
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MEP1B Overview
Facts about Meprin A subunit beta.
Meprin A subunit beta (MEP1B)
Membrane metallopeptidase that sheds many membrane-bound proteins. Exhibits a strong preference for acidic amino acids at the P1' position.
Known substrates include: FGF19, VGFA, IL1B, IL18, procollagen I and III, E-cadherin, KLK7, gastrin, ADAM10, tenascin-C. The presence of numerous pro-inflammatory cytokine one of substrates implicate MEP1B in inflammation.
Gene Information
| Human | |
|---|---|
| Gene Name: | MEP1B |
| Uniprot: | Q16820 |
| Entrez: | 4225 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
EC 3.4.24.63; endopeptidase-2; MEP1B; meprin A subunit beta; meprin A, beta; Meprin B; Meprin beta Subunit; N-benzoyl-L-tyrosyl-p-amino-benzoic acid hydrolase beta subunit; N-benzoyl-L-tyrosyl-P-amino-benzoic acid hydrolase subunit beta; PABA peptide hydrolase; PPH beta
Molecular Weight
Mass (kDA):
79.571 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 18q12.1 |
| Sequence: | 18; NC_000018.10 (32190039..32222607) |
Tissue Specificity
The major site of expression is the brush border membrane of small intestinal and kidney epithelial cells.
Subcellular Localizations
Cell membrane; Single-pass type I membrane protein. Secreted. Homodimers are essentially membrane bound but may also be shed from the surface by ADAM-10 and ADAM-17.
Diseases
- Endometrial Polyp
- Tissue Adhesions
- Kidney Diseases
- Cell Transformation, Neoplastic
- Diabetic Nephropathy
- Autosomal Recessive Polycystic Kidney Disease
- Dentin Dysplasia
- Carcinoma
- Dysplasia
- Diabetes Mellitus, Non-insulin-dependent
- Endometriosis, Site Unspecified
- Tumor Angiogenesis
Interacting Proteins
- MMP9
- TSPAN8
Pathways
- Cell Adhesion
- Transport
- Immune Response
- Odontogenesis
- Ovulation
- Localization
- Dentinogenesis
- Cell Cycle
- Cell Death
- Cell Growth
PTMs
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MEP1B
bosterbio.com/bosterbio-gene-info-cards/MEP1B
References
PMID: 9288916 by Eldering J.A., et al. Polarised expression of human intestinal N-benzoyl-L-tyrosyl-p- aminobenzoic acid hydrolase (human meprin) alpha and beta subunits in Madin-Darby canine kidney cells.
PMID: 8262185 by Dumermuth E., et al. Cloning of the PABA peptide hydrolase alpha subunit (PPH alpha) from human small intestine and its expression in COS-1 cells.