Nck-associated protein 1 Antibodies

AND NCKAP1 ELISA kits, Nck-associated protein 1 Proteins

Many biological assays use antibodies to detect Nck-associated protein 1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Nck-associated protein 1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Nck-associated protein 1 antibodies...

We validate the specificity of these antibodies to Nck-associated protein 1 by testing them on tissues known to express NCKAP1 positively and negatively. Browse below to find the NCKAP1 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Designing a Western blot for Nck-associated protein 1? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.

Open the NCKAP1 Western Blot Guide

NCKAP1 Infographic by Boster Bio

All NCKAP1 Products

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Specificity

Applications

Price

Anti-NCKAP1 Antibody Picoband®

Western blot analysis of NCKAP1 using anti-NCKAP1 antibody (A09238-1)

Human, Mouse, Rat

$370
Cat # A09238-1
100 μg/vial

NCKAP1 (NM_013436) Human Over-expression Lysate

Human

$628
Cat # LS010787
20 µg, 100 µg

NCKAP1 Overview

Facts about Nck-associated protein 1.

NCKAP1 3D structure. Source: alphafold

Nck-associated protein 1 (NCKAP1)

Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization through its interaction with the Arp2/3 complex.

Actin remodeling activity is governed by RAC1. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes.

Gene Information

Human
Gene Name:	NCKAP1
Uniprot:	Q9Y2A7
Entrez:	10787

Family

Belongs to:

HEM-1/HEM-2 family

Alternative Names

FLJ11291; HEM2p125Nap1; KIAA0587; Membrane-associated protein HEM-2; MGC8981; NAP 1; NAP125; NAP1Nap1; NCK-associated protein 1

Molecular Weight

Mass (kDA):
128.79 kDA

Genomic Context


Human

Location:	2q32.1
Sequence:	2; NC_000002.12 (182909115..183038457, complement)

Tissue Specificity

Expressed in all tissues examined except peripheral blood leukocytes, with highest expression in brain, heart, and skeletal muscle.

Subcellular Localizations

Cell membrane; Single-pass membrane protein; Cytoplasmic side. Cell projection, lamellipodium membrane; Single-pass membrane protein; Cytoplasmic side. At the interface between the lamellipodial actin meshwork and the membrane.

Diseases

Alzheimer's Disease
Neuroblastoma
Tumor Angiogenesis
Malignant Neoplasms
Cns Disorder
Neoplasms
Hemorrhage
Nervousness

Neurodegenerative Disorders
Protrusion
Wiskott-aldrich Syndrome

Interacting Proteins

ABI1
CYFIP1

Pathways

Cell Motility
Actin Nucleation
Drug Resistance
Cell Growth
Angiogenesis
Rna Interference

Secretion

PTMs

Acetylation

Research Areas

Apoptosis

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/NCKAP1

References

PMID: 10673335 by Suzuki T., et al. Molecular cloning of a novel apoptosis-related gene, human Nap1 (NCKAP1), and its possible relation to Alzheimer disease.

PMID: 25121749 by Stanton R.J., et al. HCMV pUL135 remodels the actin cytoskeleton to impair immune recognition of infected cells.