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- Table of Contents
Nicastrin Antibodies
AND NCSTN ELISA kits, Nicastrin Proteins
Many biological assays use antibodies to detect Nicastrin, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Nicastrin in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Nicastrin antibodies...
Designing a Western blot for Nicastrin? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the NCSTN Western Blot GuideDesigning an IHC experiment for Nicastrin? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the NCSTN IHC GuideNCSTN Infographic by Boster Bio
All NCSTN Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, IF, ICC, WB
$370
Cat # A03144-1
100 μg/vial
Cat # A03144-1
100 μg/vial
NCSTN Overview
Facts about Nicastrin.
Nicastrin (NCSTN)
Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein) (PubMed:10993067, PubMed:12679784, PubMed:25043039, PubMed:26280335). The gamma- secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels.
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Gene Information
| Human | |
|---|---|
| Gene Name: | NCSTN |
| Uniprot: | Q92542 |
| Entrez: | 23385 |
Family
| Belongs to: |
|---|
| nicastrin family |
Alternative Names
anterior pharynx-defective 2; APH2; ATAG1874; KIAA0253APH2; NCSTN; Nicastrin
Molecular Weight
Mass (kDA):
78.411 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 1q23.2 |
| Sequence: | 1; NC_000001.11 (160343328..160358949) |
Tissue Specificity
Detected in brain (at protein level) (PubMed:10993067). Widely expressed (PubMed:11396676).
Subcellular Localizations
Membrane; Single-pass type I membrane protein. Cytoplasmic vesicle membrane; Single-pass type I membrane protein. Melanosome. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Diseases
- Alzheimer's Disease
- Hidradenitis
- Hidradenitis Suppurativa
- Acne
- Dementia
- Malignant Neoplasms
- Alteration Of Cognitive Function
- Impaired Cognition
- Cholangiocarcinoma
- Abscess
- Neurodegenerative Disorders
- Hypoxia
- Malignant Neoplasm Of Urinary Bladder
Interacting Proteins
- APH1A
- PSEN1
- PSENEN
- TMED10
Pathways
- Pathogenesis
- Transport
- Cognition
- Histone H3 Acetylation
- Viral Latency
- Dna Recombination
- Nuclear Export
PTMs
- Cleavage
- Gamma-cleavage
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/NCSTN
bosterbio.com/bosterbio-gene-info-cards/NCSTN
References
PMID: 10993067 by Yu G., et al. Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing.
PMID: 11396676 by Satoh J., et al. Nicastrin, a key regulator of presenilin function, is expressed constitutively in human neural cell lines.