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- Table of Contents
Ndfip1 Antibodies
AND Ndfip1 ELISA kits, Ndfip1 Proteins
Many biological assays use antibodies to detect Ndfip1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Ndfip1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Ndfip1 antibodies...
Designing an IHC experiment for Ndfip1? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the NDFIP1 IHC GuideNdfip1 Infographic by Boster Bio
All Ndfip1 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, Flow Cytometry, WB
$370
Cat # A04644-2
100 μg/vial
Cat # A04644-2
100 μg/vial
Ndfip1 Overview
Facts about NEDD4 family-interacting protein 1.
NEDD4 family-interacting protein 1 (Ndfip1)
Activates HECT domain-containing E3 ubiquitin-protein ligases, including NEDD4 and ITCH, and consequently modulates the stability of the targets. Because of this, controls many cellular processes.
Prevents chronic T-helper cell-mediated inflammation by activating ITCH and so controlling JUNB degradation (PubMed:11748237, PubMed:17137798, PubMed:20962770). Promotes pancreatic beta cell death through degradation of JUNB and inhibition of the unfolded protein response, leading to decrease of insulin secretion (PubMed:26319551).
Gene Information
| Mouse | |
|---|---|
| Gene Name: | Ndfip1 |
| Uniprot: | Q8R0W6 |
| Entrez: | 65113 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
Breast cancer-associated protein SGA-1M; MGC10924; N4WBP5; N4WBP5Putative NF-kappa-B-activating protein 164; NDFIP1; Nedd4 family interacting protein 1; NEDD4 family-interacting protein 1; NEDD4 WW domain-binding protein 5; Putative MAPK-activating protein PM13; Putative NFKB and MAPK-activating protein
Molecular Weight
Mass (kDA):
24.914 kDA
Genomic Context
| Mouse | |
|---|---|
| Location: | 18|18 B3 |
| Sequence: | 18; |
Tissue Specificity
Highly expressed in embryonic and early postnatal cortex (at protein level) (PubMed:23897647). Widely expressed (PubMed:11748237). Hardly detectable in resting T-cells; up-regulated in T-cells in response to activation (PubMed:17137798).
Diseases
- Inflammation
- Neoplasms
- Brain Ischemia
- Inflammatory Bowel Diseases
- Intestinal Diseases
- Malignant Neoplasms
- Cerebral Ischemia
- Brain Injuries
- Ischemia
- Inflammatory Disorder
- Intrinsic Asthma
- Liddle Syndrome
- Infarction
Pathways
- Transport
- Cell Activation
- T Cell Activation
- Localization
- Cell Death
- Secretion
- Regulation Of Metal Ion Transport
- Proteolysis
- Ion Transport
- Hypersensitivity
- Inflammatory Response
- Neuroprotection
- Reverse Transcription
PTMs
- Ubiquitination
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Ndfip1
bosterbio.com/bosterbio-gene-info-cards/Ndfip1
References
PMID: 11042109 by Jolliffe C.N., et al. Identification of multiple proteins expressed in murine embryos as binding partners for the WW domains of the ubiquitin-protein ligase Nedd4.
PMID: 11748237 by Harvey K.F., et al. N4WBP5, a potential target for ubiquitination by the Nedd4 family of proteins, is a novel Golgi-associated protein.